Results 141 to 150 of about 215,248 (308)

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation [PDF]

, 2015
Anastasia I. Petra, Smaro Panagiotidou, Erifili Hatziagelaki, Julia M. Stewart, Pio Conti, Theoharis C. Theoharides   +5 more
openalex   +1 more source

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station

Journal of Allergy and Clinical Immunology: Global
A case report detailing, for the first time, a case of laboratory-confirmed zoster in an astronaut on board the International Space Station is presented.
Satish K. Mehta, PhD, Rahul Suresh, MD, Keith Brandt, MD, Douglass M. Diak, PhD, Scott M. Smith, PhD, Sara R. Zwart, PhD, Grace Douglas, PhD, Mayra Nelman-Gonzalez, BA, Simon Clemett, PhD, Tyson Brunstetter, OD, PhD, Brian E. Crucian, PhD   +10 more
doaj  

Severe immune dysregulation with neurological impairment and minor bone changes in a child with spondyloenchondrodysplasia due to two novel mutations in the ACP5 gene [PDF]

, 2015
Hermann Girschick, Christine Wolf, Henner Morbach, Christoph Hertzberg, Min Ae Lee‐Kirsch   +4 more
openalex   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Research Progress on Inflammation and Immune Dysregulation in PTSD. [PDF]

Brain Behav
Yang L, Lu J, Zhao Z, Zhang Z, Yang W, Zhang G.   +5 more
europepmc   +1 more source

Is Immune Dysregulation Involved in the Aetiology of Exertional Heat Illness (EHI)?

, 2010
James Bilzon, Simon K. Jackson, Adam Harper-Smith, Matthew B. Fortes, Bethany Dement, Neil P. Walsh   +5 more
openalex   +1 more source

Ocular Manifestations of Inherited Phospholipase-Cγ2–Associated Antibody Deficiency and Immune Dysregulation [PDF]

, 2016
Antonio Di Zazzo, Maryam Tahvildari, George J. Florakis, Reza Dana   +3 more
openalex   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source