Results 141 to 150 of about 236,691 (313)

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation [PDF]

, 2015
Anastasia I. Petra, Smaro Panagiotidou, Erifili Hatziagelaki, Julia M. Stewart, Pio Conti, Theoharis C. Theoharides   +5 more
openalex   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Severe immune dysregulation with neurological impairment and minor bone changes in a child with spondyloenchondrodysplasia due to two novel mutations in the ACP5 gene [PDF]

, 2015
Hermann Girschick, Christine Wolf, Henner Morbach, Christoph Hertzberg, Min Ae Lee‐Kirsch   +4 more
openalex   +1 more source

Cuproptosis Signature Would Reveal the Acute‐Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
Neuromyelitis optica spectrum disorder (NMOSD) has distinct acute‐remitting courses but lacks biomarkers for predicting relapse. Recent studies found cuproptosis‐related genes affect its course, and a model built accordingly can predict relapse to aid intervention.
Peidong Liu, Ruoyu Li, Xinlin Wang, Hui Li, Huiru Hu, Ang Shen, Wenping Zhu, Jiali Pan, Yanmeng Xing, Weiming Xia, Henan Jiao, Di Chen, Lixin Wu, Li Liu, Ju Liu, Bin Yu, Xianzhi Liu, Hongbo Liu   +17 more
wiley   +1 more source

Chronic Infection by Mucoid Pseudomonas aeruginosa Associated with Dysregulation in T-Cell Immunity to Outer Membrane Porin F [PDF]

, 2015
Kathryn Quigley, Catherine J. Reynolds, Amélie Goudet, Eleanor J Raynsford, Ruhena Sergeant, Andrew Quigley, Stefan Worgall, Diana Bilton, Robert Wilson, Michael R. Loebinger, Bernard Maillère, Daniel M. Altmann, Rosemary J. Boyton   +12 more
openalex   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging. [PDF]

J Med Virol
Novazzi F, Spezia PG, Ferrante FD, Genoni AP, Grossi PA, Mancini N, Malavolta M, Ballietti M, Piacenza F, Marcozzi S, Fortunato C, Badillo Pazmay GV, Cianfruglia L, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Zampieri M, Caiafa P, Ciccarone F, Reale A, Weinberger B, Sikora E, Debacq-Chainiaux F, Stuetz W, Hurme M, Slagboom PE, Bernhardt J, Olivieri F, Filippini F, Maggi F, Giacconi R.   +35 more
europepmc   +1 more source

Immune dysregulation in patients with TRNT1 deficiency [PDF]

, 2015
Angeliki Giannelou, Qingwen Zhou, Monique Stoffels, D Stone, Amanda K. Ombrello, Karyl S. Barron, Helen C. Su, Kimberly Risma, Lucie Šrámková, Anna Šedivá, Sarita Joshi, Abdullah Al Sonbul, Hong‐Wei Sun, Marcello Quezado, Massimo Gadina, Ivona Aksentijevich, DL Kastner   +16 more
openalex   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Atopic dermatitis in inborn errors of immunity: at the interface of immunodeficiency and immune dysregulation. [PDF]

Immunol Res
Szczawińska-Popłonyk A.
europepmc   +1 more source