Results 151 to 160 of about 215,248 (308)

Immune Dysregulation and Prognosis in Sepsis: Insights From a Posttranslational Perspective. [PDF]

Hum Mutat
Ye Y, Chen Q, Wu D, Yu G, Liu J, Li Y, Xu Z, Lin L.   +7 more
europepmc   +1 more source

HIV Infection «HIV Tat Protein, a Key Factor in Pathogenesis and Immune System Dysregulation: Implication of IL-10»

, 2011
Ben Haij, Rémi Planès, Olfa Mzoughi, Elmostafa Bahraoui   +3 more
openalex   +2 more sources

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Editorial: Microbial dysbiosis and immune dysregulation in periodontitis and peri-implantitis. [PDF]

Front Cell Infect Microbiol
Morandini AC, Gangula PR, Li Y, Deng K.
europepmc   +1 more source

The biomarkers of immune dysregulation and inflammation response in Parkinson disease [PDF]

, 2016
Li Chen, Mingshu Mo, Guangning Li, Luan Cen, Lei Wei, Yousheng Xiao, Xiang Chen, Shaomin Li, Xinling Yang, Shaogang Qu, Pingyi Xu   +10 more
openalex   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Cutaneous and Gut Dysbiosis in Alopecia Areata: A Review

JID Innovations
Alopecia areata (AA) is a common, immune-mediated nonscarring alopecia. Breakdown of immune privilege combined with local immune cell infiltration is central to the development of AA; yet, the instigating factors causing immune dysregulation remain ...
Nicole E. Burma, Michele L. Ramien
doaj  

Unraveling R-loops: The hidden drivers of inflammation and immune dysregulation. [PDF]

Medicine (Baltimore)
Zhang F, Wang D, Zhao G, Wang D.
europepmc   +1 more source

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Advanced Science, EarlyView.
Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin   +10 more
wiley   +1 more source

Editorial: Innate immune dysregulation: a driving force of autoimmunity and chronic inflammation. [PDF]

Front Immunol
Akbarzadeh R, Humrich JY, Németh T, Amber KT.   +3 more
europepmc   +1 more source