Results 161 to 170 of about 236,691 (313)

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Ocular Manifestations of Inherited Phospholipase-Cγ2–Associated Antibody Deficiency and Immune Dysregulation [PDF]

, 2016
Antonio Di Zazzo, Maryam Tahvildari, George J. Florakis, Reza Dana   +3 more
openalex   +1 more source

Single‐Cell Transcriptomics Unravels Growth Factor Erv1‐Like Mediated Ferroptosis as a Key Driver of Intestinal Epithelial Dysfunction in Ulcerative Colitis

Advanced Science, EarlyView.
Single‐cell transcriptomic profiling of ulcerative colitis (UC) tissues identified downregulation of GFER in intestinal epithelial cells. Mechanistically, GFER interacts with PCBP1 to help maintain intracellular iron homeostasis and may also reduce lipid peroxidation by activating the PGC‐1α/PPARγ signaling pathway, thereby inhibiting ferroptosis ...
Ya Song, Fangyan Tan, Qian Song, Xiaohui Liao, Zhechuan Mei, Lin Lv   +5 more
wiley   +1 more source

PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome. [PDF]

Front Immunol
Ma H, Qi D, Xu Y, Shang T, Si Y, Chen W, Zhao H, Ren Q.   +7 more
europepmc   +1 more source

Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge [PDF]

, 2016
Rachel K. Rowe, Gavin I. Ellis, Jordan L. Harrison, Adam D. Bachstetter, Gregory Corder, Linda J. Van Eldik, Bradley K. Taylor, Francesc Martí, Jonathan Lifshitz   +8 more
openalex   +1 more source

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

Advanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao, Yixing Huang, Mingcong Deng, Chunkai Zhang, Dan Zu, Hanyi He, Yangchan Hu, Yuke Zhong, Chen Liang, Haidong Liu, Wumin Dai, Yanhua He, Yaoshu Teng, Ji Jing, Yin Shi, Xiangdong Cheng, Zu Ye   +16 more
wiley   +1 more source

Prospective Examination of Cellular and Soluble Mediators of Immune Dysregulation and Their Association with Lung Cancer Risk. [PDF]

Cancer Epidemiol Biomarkers Prev
Sivagnanalingam U, Demanelis K, Wang R, Yuan JM, Finn OJ.   +4 more
europepmc   +1 more source

ATP Binding Cassette Transporter G1 Deletion Induces IL-17–Dependent Dysregulation of Pulmonary Adaptive Immunity

, 2012
David W. Draper, Kymberly M. Gowdy, Jennifer H. Madenspacher, Rhonda H. Wilson, Gregory S. Whitehead, Hideki Nakano, Arun R. Pandiri, Julie F. Foley, Alan T. Remaley, Donald N. Cook, Michael B. Fessler   +10 more
openalex   +1 more source

The TH1 phenotype of follicular helper T cells indicates an IFN-γ–associated immune dysregulation in patients with CD21low common variable immunodeficiency [PDF]

, 2017
Susanne Unger, Maximilian Seidl, Pauline A. van Schouwenburg, Mirzokhid Rakhmanov, Alla Bulashevska, Natalie Frede, Bodo Grimbacher, Jens Pfeiffer, Klaudia Schrenk, Luis E. Muñoz, Leif G. Hanitsch, Ina Stumpf, Fabian Kaiser, Oliver Hausmann, Florian Kollert, Sigune Goldacker, Mirjam van der Burg, Baerbel Keller, Klaus Warnatz   +18 more
openalex   +1 more source

Atherosclerosis as an immune dysregulation

Sang thrombose vaisseaux, 2018
openaire   +2 more sources