Results 171 to 180 of about 215,248 (308)

288 Immune dysregulation in morphea [PDF]

, 2017
Neeta Malviya, Nika Cyrus, Jacob Turner, Heidi Jacobe   +3 more
openalex   +1 more source

Atherosclerosis as an immune dysregulation

Sang thrombose vaisseaux, 2018
openaire   +2 more sources

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

Advanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu, Qianmin Ou, Qianhui Ren, Zhengshi Li, Hongcheng Chen, Fangcao Lei, Xueli Mao, Songtao Shi, Zetao Chen, Wei Teng   +9 more
wiley   +1 more source

Carbohydrate malabsorption mimicking immune dysregulation: A histological challenge. [PDF]

JPGN Rep
Eroglu S, Nandolia S, Zhang Y, Voltaggio L, Guerrerio AL.   +4 more
europepmc   +1 more source

The TH1 phenotype of follicular helper T cells indicates an IFN-γ–associated immune dysregulation in patients with CD21low common variable immunodeficiency [PDF]

, 2017
Susanne Unger, Maximilian Seidl, Pauline A. van Schouwenburg, Mirzokhid Rakhmanov, Alla Bulashevska, Natalie Frede, Bodo Grimbacher, Jens Pfeiffer, Klaudia Schrenk, Luis E. Muñoz, Leif G. Hanitsch, Ina Stumpf, Fabian Kaiser, Oliver Hausmann, Florian Kollert, Sigune Goldacker, Mirjam van der Burg, Baerbel Keller, Klaus Warnatz   +18 more
openalex   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Immune Dysregulation as a Cause of Autoinflammation in Fragile X Premutation Carriers: Link between FMRI CGG Repeat Number and Decreased Cytokine Responses

, 2014
Milo Careaga, Destanie R. Rose, Flora Tassone, Robert F. Berman, Randi J. Hagerman, Paul Ashwood   +5 more
openalex   +2 more sources

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

Advanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti, Xinyuan Jiang, Xiuying Chen, Mingshu Xiao, Sujing Jiang, Yun Xu, Peng Xiao, Jiangnan Zhao, Kaiyue Zhang, Mengshu Li, Kai Wang   +14 more
wiley   +1 more source

Immune Dysregulation at the Maternal-Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model. [PDF]

Biomedicines
Yang C, Li W, Liu X, Ma Z, Chen J, Gong Q, Braunstein Z, Rao X, Wei Y, Zhong J.   +9 more
europepmc   +1 more source

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

, 2015
Bernice Lo, Kejian Zhang, Wei Lü, Lixin Zheng, Qian Zhang, Chrysi Kanellopoulou, Yu Zhang, Zhiduo Liu, Jill M. Fritz, Rebecca Marsh, Ammar Husami, Diane Kissell, Shannon Nortman, Vijaya Chaturvedi, Hilary Haines, Lisa R. Young, Jun Mo, Alexandra H. Filipovich, Jack Bleesing, Peter Mustillo, Michael C. Stephens, Cesar M. Rueda, Claire Chougnet, Kasper Hoebe, Joshua McElwee, Jason D. Hughes, Elif Karakoç-Aydıner, Helen Matthews, Susan Price, Helen C. Su, V. Koneti Rao, Michael J. Lenardo, Michael B. Jordan   +32 more
openalex   +1 more source