Results 181 to 190 of about 236,691 (313)

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

, 2015
Bernice Lo, Kejian Zhang, Wei Lü, Lixin Zheng, Qian Zhang, Chrysi Kanellopoulou, Yu Zhang, Zhiduo Liu, Jill M. Fritz, Rebecca Marsh, Ammar Husami, Diane Kissell, Shannon Nortman, Vijaya Chaturvedi, Hilary Haines, Lisa R. Young, Jun Mo, Alexandra H. Filipovich, Jack Bleesing, Peter Mustillo, Michael C. Stephens, Cesar M. Rueda, Claire Chougnet, Kasper Hoebe, Joshua McElwee, Jason D. Hughes, Elif Karakoç-Aydıner, Helen Matthews, Susan Price, Helen C. Su, V. Koneti Rao, Michael J. Lenardo, Michael B. Jordan   +32 more
openalex   +1 more source

Immune Dysregulation: Differentiating Between Unipolar and Bipolar Disorder [PDF]

, 2017

openalex   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Genetic damage and immune dysregulation in Schistosoma haematobium-infected individuals in Nigeria. [PDF]

BMC Immunol
Olaniyan MF, Odegbemi OB, Iyare GI, Alaka OO, Adepoju AL.   +4 more
europepmc   +1 more source

Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction

Advanced Science, EarlyView.
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu, Huitong Ruan, Xiaolin Zhang, Weihan Zheng, Muhetaierjiang Mutailifu, Ling Wang, Liu Yu, Ruijun Peng, Rui Zhao, Zihan Wang, Jie Xu, Shaochuan Li, Yaobin Wu, Wenguo Cui, Mujun Lu   +14 more
wiley   +1 more source

ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk. [PDF]

Brain Behav
Sun F, Lu G, Li N, Dai K, Ren Z, Ma R, Feng Y, Zong S, Cheng B.   +8 more
europepmc   +1 more source

A Wide Spectrum of Autoimmune Manifestations and Other Symptoms Suggesting Immune Dysregulation in Patients With Cartilage-Hair Hypoplasia [PDF]

, 2018
Svetlana Vakkilainen, Riikka E. Mäkitie, Paula Klemetti, Helena Valta, Mervi Taskinen, Eystein S. Husebye, Outi Mäkitie   +6 more
openalex   +1 more source

Tackling Allergic Airway Inflammation with Organic Sheet‐Like Nanoplatforms by Targeted Elimination of Epithelial Small Extracellular Vesicles

Advanced Science, EarlyView.
In this work, “inorganic‐free” nanosheets, named PNSE are developed using template‐based synthesis technology. The functionalized organic nanosheets exhibit low cytotoxicity, mild protein adsorption, and potent binding efficacy to epithelial sEVs.
Zhaoxu Tu, Junyan Lin, Zhixin Li, Yuefei Zhu, Changyi Xu, Zihan Qiu, Qiumin Wang, Yang Ye, Yihui Wen, Jian Li, Kam W. Leong, Weiping Wen   +11 more
wiley   +1 more source

Bibliometric analysis of immune dysregulation and immunotherapy in mismatch repair-deficient colon cancer. [PDF]

Discov Oncol
Jin X, Wang H, Han Y, Yang M, Ye Q, Wang Q, Zheng, Mei Z.   +7 more
europepmc   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source