Results 11 to 20 of about 236,691 (313)
Immune dysregulation in myelodysplastic syndrome
Hematology Reports, 2010 Myelodysplastic syndrome (MDS) represents one of the most challenging health-related problems in the elderly. Characterized by dysplastic morphology in the bone marrow in association with ineffective hematopoiesis, pathophysiological causes of this ...
Chiharu Sugimori +2 more
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Immune Dysregulation in Children With Down Syndrome [PDF]
Frontiers in Pediatrics, 2020 Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune dysregulation in DS is substantial, spanning the innate and adaptive systems and including anomalies in: T and B cells, monocytes, neutrophil ...
Dean Huggard +10 more
doaj +6 more sources
Immune‐dysregulation harnessing in myeloid neoplasms
Cancer MedicineMyeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression.
Mohammad Jafar Sharifi +5 more
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Immune dysregulation in severe influenza [PDF]
Journal of Leukocyte Biology, 2009 AbstractAmong previously healthy children with severe influenza, the mechanisms leading to increased pathology are not understood. We hypothesized that children with severe influenza would have high levels of circulating cytokines. To examine this, we recruited patients with severe influenza and examined plasma cytokine levels as well as the ability of
Meredith Heltzer +6 more
openalex +5 more sources
Journal of Allergy and Clinical Immunology, 2023 The understanding of immune dysregulation in many different diseases continues to grow. There is increasing evidence that altered microbiome and gut barrier dysfunction contribute to systemic inflammation in patients with primary immunodeficiency and in patients with rheumatic disease.
Andrew, Long +2 more
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Immune Dysregulation in Immune Thrombocytopenia [PDF]
Seminars in Hematology, 2013 Immune thrombocytopenia (ITP) is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. A shift toward Th1 and possibly Th17 cells together with impaired regulatory compartment, including T-regulatory (Tregs) and B-regulatory (Bregs) cells, have ...
Weili Bao +2 more
openaire +3 more sources
Depression, dementia and immune dysregulation [PDF]
Brain, 2020 AbstractMajor depression is a prevalent illness that increases the risk of several neurological conditions. These include stroke, cardiovascular disease, and dementia including Alzheimer’s disease. In this review we ask whether certain types of depression and associated loneliness may be a harbinger of cognitive decline and possibly even dementia.
Shawn Hayley +2 more
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Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine
Frontiers in Immunology, 2020 Objective: To assess the efficiency of the endometrial immune profiling as a method to design personalized care to enhance the pregnancy rate in a large heterogeneous infertile population.
Nathalie Lédée +10 more
doaj +1 more source
Microvascular significance of TGF-β axis activation in COVID-19
Frontiers in Cardiovascular Medicine, 2023 As 2023 approaches, the COVID-19 pandemic has killed millions. While vaccines have been a crucial intervention, only a few effective medications exist for prevention and treatment of COVID-19 in breakthrough cases or in unvaccinated or immunocompromised ...
Lauren M. Arguinchona +6 more
doaj +1 more source
Lentivirus-induced immune dysregulation [PDF]
Veterinary Immunology and Immunopathology, 2008 FIV/HIV infections are associated with an early robust humoral and cellular anti-viral immune response followed by a progressive immune suppression that eventually results in AIDS. Several mechanisms responsible for this immune dysfunction have been proposed including cytokine dysregulation, immunologic anergy and apoptosis, and inappropriate ...
Mary B. Tompkins, Wayne A. F. Tompkins
openaire +2 more sources