Results 191 to 200 of about 215,248 (308)

Managing immune dysregulation resulting from immune checkpoint inhibitors: impact of the ASCO guidelines and key take-homes for immunologists [PDF]

, 2018
Sang T. Kim, María E. Suärez-Almazor
openalex   +1 more source

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source

Polyautoimmunity Reflecting Immune Dysregulation in Common Variable Immunodeficiency. [PDF]

Biomedicines
Danieli MG, Murdaca G, Mezzanotte C, Claudi I, Buti E, Martini M, Bilò MB, Gangemi S, Moroncini G.   +8 more
europepmc   +1 more source

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

Advanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge, Shuying Wang, Zhaokai Li, Jing Yu, Binbin Liu, Ruiying Wang, Shichen Bu, Nawsher wan, Yan Wang, Cuilian Dai, Yijun Lin   +10 more
wiley   +1 more source

International multidisciplinary consensus on the definition and clinical approach for monogenic inflammatory immune dysregulation disorders. [PDF]

Pediatr Rheumatol Online J
Alkwai HM, Almaghlouth IA, Mendonça LO, Elkhalifa S, Abolhassani H, Aljumaah S, Al-Mousa H, Alosaimi MF, AlSaleem A, Avcin T, Chan WK, Espada G, Frémond ML, Gül A, Hadef D, Movahedi N, Wittkowski H, Al-Mayouf SM.   +17 more
europepmc   +1 more source

Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary Immunodeficiencies

, 2016
Jolán E. Walter, Jocelyn R. Farmer, Zsófia Földvári, Troy R. Torgerson, Megan A. Cooper   +4 more
openalex   +1 more source

A Wide Spectrum of Autoimmune Manifestations and Other Symptoms Suggesting Immune Dysregulation in Patients With Cartilage-Hair Hypoplasia [PDF]

, 2018
Svetlana Vakkilainen, Riikka E. Mäkitie, Paula Klemetti, Helena Valta, Mervi Taskinen, Eystein S. Husebye, Outi Mäkitie   +6 more
openalex   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source

Immune dysregulation as a driver of bronchiolitis obliterans. [PDF]

Front Immunol
Deng K, Lu G.
europepmc   +1 more source

PTf‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei, Yichun Pan, Jie Zhai, Tongqing Li, Yuxin Zhou, Sheyu Zhang, Juan Wei, Qian Hu, Xueying Liu, Lu Guo, Weizhu Wu, Yong Wei, Qin Wu, Weihong Tan   +13 more
wiley   +1 more source