Results 221 to 230 of about 2,310,452 (384)

Immune dysregulation in employees of the ferrous metallurgy enterprise under conditions of excessive vanadium contamination

, 2020
Оleg V. Dolgikh, В. Б. Алексеев, Д. Г. Дианова, А. В. Кривцов   +3 more
openalex   +1 more source

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

, 2021
Lin Wang, Dominik Aschenbrenner, Zhiyang Zeng, Xiya Cao, Daniel Mayr, Meera Mehta, Melania Capitani, Neil Warner, Jie Pan, Liren Wang, Li Qi, Tao Zuo, Sarit Cohen‐Kedar, Jiawei Lu, Rico Chandra Ardy, Daniel J. Mulder, Dilan Dissanayake, Kaiyue Peng, Zhiheng Huang, Xiaoqin Li, Yuesheng Wang, Xiaobing Wang, Shuchao Li, Samuel J. Bullers, Anís N. Gammage, Klaus Warnatz, Ana‐Iris Schiefer, Gergely Kriván, Vera Goda, Walter H.A. Kahr, Mathieu Lemaire, Helen Griffin, Sophie Hambleton, Chien-Yi Lu, Iram Siddiqui, Michael G. Surette, Daniel Kotlarz, Karin R. Engelhardt, Helen Griffin, Robert Rottapel, Hélène Decaluwe, Ronald M. Laxer, Michele Proietti, Sophie Hambleton, Suzanne Elcombe, Conghui Guo, Bodo Grimbacher, Iris Dotan, Siew C. Ng, Spencer A. Freeman, Scott B. Snapper, Christoph Klein, Kaan Boztuǧ, Ying Huang, Dali Li, Holm H. Uhlig, Aleixo M. Muise   +56 more
openalex   +2 more sources

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Immune Dysregulation in Sepsis. A Narrative Review for the Clinicians. [PDF]

Biomedicines
Valsamaki A, Vazgiourakis V, Mantzarlis K, Manoulakas E, Makris D.   +4 more
europepmc   +1 more source

Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration [PDF]

, 2018
Agarwal, Betel, Dong, Gehlbach, Gerrity, Gerrity, Ménard, Nakamura, Paraskevopoulou, Peled, Vlachos, Wong   +11 more
core   +2 more sources

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Immune dysregulation driven by elevated platelet-to-lymphocyte ratio aggravates myasthenia gravis. [PDF]

J Int Med Res
Luo S, Song Z, Zhawatibai A, Qiu Y, Li M, Zhu Y, Yu Y, Zhou M, Hong D.   +8 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Immune Dysregulation and Cytokine Profiling in Acute <i>Mycoplasma pneumoniae</i> Pneumonia. [PDF]

Microorganisms
Wen Y, Zhai Y, Sang S, Cao C, Mao Y, Hu E, Zhai L, Ye X, Li K, Wang Y, Yu R.   +10 more
europepmc   +1 more source

CDH1 Deficiency Orchestrates Epithelial-Immune Dysregulation in Active Inflammatory Bowel Disease: A Multi-Omics Approach Linking Biomarker Discovery to Therapeutic Targets

Ming Chen, Tao Yin
openalex   +1 more source