Results 221 to 230 of about 236,691 (313)

Unraveling R-loops: The hidden drivers of inflammation and immune dysregulation. [PDF]

Medicine (Baltimore)
Zhang F, Wang D, Zhao G, Wang D.
europepmc   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

The double-edged sword of PI3Kδ pathway-related immune dysregulation: insights from two case reports. [PDF]

Immunol Res
Cabanero-Navalon MD, Garcia-Bustos V, Ibanez-Barcelo S, Balastegui-Martin H, Grimaldos-Lodares J, Moral-Moral P.   +5 more
europepmc   +1 more source

Neutrophil and Granulocytic Myeloid-Derived Suppressor Cell–Mediated T Cell Suppression Significantly Contributes to Immune Dysregulation in Common Variable Immunodeficiency Disorders

, 2018
Marcela Vlková, Zita Chovancová, Jana Nechvátalová, Ashley N. Connelly, Marcus D. Davis, Peter Slanina, Lucie Travnickova, Marek Litzman, Tereza Grymová, Přemysl Souček, Tomáš Freiberger, Jiří Litzman, Zdeněk Hel   +12 more
openalex   +1 more source

Mitochondrial Transplantation Augments the Reparative Capacity of Macrophages Following Myocardial Injury

Advanced Science, EarlyView.
Mitochondrial transplantation induces macrophage polarization toward an anti‐inflammatory M2 phenotype, enhances their reparative capacities, and facilitates mitochondrial transfer to cardiomyocytes, collectively promoting tissue repair and functional recovery post‐myocardial infarction.
Yuning Zhang, Xiaolei Sun, Yawei Jin, Kanghui Chen, Lu Zhang, Xiong Gao, Mohan Li, Ze Yuan, Jianguo Jia, Aijun Sun, Junbo Ge   +10 more
wiley   +1 more source

Epstein-Barr Virus Seropositivity, Immune Dysregulation, and Mortality in Pediatric Sepsis.

JAMA Netw Open
Sriram A, Kernan KF, Qin Y, Aldewereld Z, Walton AH, Cabler S, Storch G, Cheynet V, Brengel-Pesce K, Canna S, Carcillo JA, Berg RA, Meert KL, Pollack M, Hall M, Newth K, Harrison R, Shanley T, Remy KE, Park HJ.   +19 more
europepmc   +1 more source

A Herbal‐Piezoelectric Heterojunction Strategy to Potentiate Bacterial Cuproptosis‐Like Death and Remodel the Inflammatory Microenvironment in Infection‐Associated Implant Osteomyelitis

Advanced Science, EarlyView.
A titanium implant coating integrating berberine and copper‐doped strontium titanate leverages ultrasound to compromise bacterial membranes and induce cuproptosis‐like death. This approach resolves S. aureus infections in osteomyelitis models while suppressing inflammation and promoting osseointegration, demonstrating a dual‐functional strategy against
Guannan Zhang, Zehao Li, Ying Lu, Jianbo Song, Xingyu Liang, Peide Han, Xiaohong Yao, Yongqiang Yang, Xiangyu Zhang   +8 more
wiley   +1 more source

Melatonin as the Missing Link Between Sleep Deprivation and Immune Dysregulation: A Narrative Review. [PDF]

Int J Mol Sci
Szataniak I, Packi K.
europepmc   +1 more source

Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations

, 2018
Lisa R. Forbes, Tiphanie P. Vogel, Megan A. Cooper, Johana B Castro-Wagner, Edith Schussler, Katja G. Weinacht, Ashley Plant, Helen C. Su, Eric J. Allenspach, Mary Slatter, Mario Abinun, Desa Lilić, Charlotte Cunningham‐Rundles, Olive S. Eckstein, Peter Olbrich, R. Paul Guillerman, Niraj Patel, Yeşim Yılmaz Demirdağ, Christa S. Zerbe, Alexandra F. Freeman, Steven M. Holland, Paul Szabolcs, Andrew R. Gennery, Troy R. Torgerson, Joshua D. Milner, Jennifer W. Leiding   +25 more
openalex   +1 more source