Results 221 to 230 of about 215,248 (308)

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

The role of immune dysregulation in the pathogenesis of type 1 diabetes: a paradigm shift in prevention strategies. [PDF]

EXCLI J
Gopalsamy RG, Govindasamy H, de Souza JB, Silva DMRR, Moura PHM, Santos RS, Barreto MDS, Guimarães AG, Santana LADM, Borges LP, Silva EED.   +10 more
europepmc   +1 more source

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Advanced Science, EarlyView.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye, Gaëlle Champeil‐Potokar, Marie‐Sabelle Hjeij, Gwénaëlle Randuineau, Léa Le Gleau, Selma Ben Fradj, Catherine Philippe, Alexandre Benani, Isabelle Denis, Véronique Douard, Gaëlle Boudry   +13 more
wiley   +1 more source

Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations

, 2018
Lisa R. Forbes, Tiphanie P. Vogel, Megan A. Cooper, Johana B Castro-Wagner, Edith Schussler, Katja G. Weinacht, Ashley Plant, Helen C. Su, Eric J. Allenspach, Mary Slatter, Mario Abinun, Desa Lilić, Charlotte Cunningham‐Rundles, Olive S. Eckstein, Peter Olbrich, R. Paul Guillerman, Niraj Patel, Yeşim Yılmaz Demirdağ, Christa S. Zerbe, Alexandra F. Freeman, Steven M. Holland, Paul Szabolcs, Andrew R. Gennery, Troy R. Torgerson, Joshua D. Milner, Jennifer W. Leiding   +25 more
openalex   +1 more source

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

Advanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen, Ze Wang, Chenglong Sun, Yang Zhong, Yuan Liu, Yikun Li, Tongchao Zhang, Yuan Zhang, Xingyu Zhu, Leping Li, Feifei Teng, Ming Lu, Wei Chong   +12 more
wiley   +1 more source

Immune Dysregulation in Acute Herpes Zoster: Predictive Factors for Postherpetic Neuralgia. [PDF]

Med Sci Monit
Wang M, Yuan Y, Wang J, Yan Y, Yu H.
europepmc   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan, Jie Mei, Yun Cai, Ji Zhou, Ningyi Xue, Ying Jiang, Yan Zhang, Jingjing Huang, Yichao Zhu   +8 more
wiley   +1 more source

Atopic Dermatitis Immune Dysregulation as Dengue Predisposing Factor. [PDF]

J Inflamm Res
Astuti RDI, Alam A, Ghozali M, Setiabudiawan B.   +3 more
europepmc   +1 more source

Prenatal Stress, Maternal Immune Dysregulation, and Their Association With Autism Spectrum Disorders

, 2018
David Q. Beversdorf, Hanna E. Stevens, Karen L. Jones   +2 more
openalex   +2 more sources

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source