Results 231 to 240 of about 2,310,452 (384)

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Topoisomerase III-beta protects from immune dysregulation and tumorigenesis. [PDF]

Sci Adv
Al Mahmud MR, Baechler SA, Dhall A, Saha S, Zhang H, Bassel L, Zhang S, Lee MJ, Sato N, Rastogi S, Kumar S, Alam MS, Saha LK, Mock BA, Factor VM, Pommier Y.   +15 more
europepmc   +1 more source

Table 3_Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface.xlsx

Eszter Tóth (533509), Máté Posta (14306222), Dániel Györffy (22134829), Orsolya Oravecz (14306216), Emese Farkas (6082226), Andrea Balogh (618197), Claudia Escher (19774700), Magdalena Bober (22134832), András Szilágyi (2490475), Petronella Hupuczi (6856163), Lajos Veress (22134835), Olga Török (17999563), Sándor Nagy (2462479), Oliver Rinner (1575586), Offer Erez (212386), Zoltán Papp (5656855), Nándor Ács (15224992), Nándor Gábor Than (14306225)   +17 more
openalex   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Biofilm-mediated immune dysregulation in chronic pulmonary diseases: mechanisms and clinical implications. [PDF]

Front Microbiol
Yu X, Zhang Y, Yao Y, Cho WC, Shang A.
europepmc   +1 more source

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, EarlyView.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source

Microbiota-Driven Immune Dysregulation Along the Gut-Lung-Vascular Axis in Asthma and Atherosclerosis. [PDF]

Biomedicines
Zimbru EL, Zimbru RI, Bojin FM, Chiriac SD, Haidar L, Andor M, Tănasie G, Tatu C, Georgescu M, Uța C, Bănărescu CF, Groza S, Panaitescu C.   +12 more
europepmc   +1 more source

Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells [PDF]

Sandra M. Martín‐Guerrero, María Martín‐Estebané, Antonio Jesús Lara Ordóñez, Manuel Cánovas, David Martín‐Oliva, Javier González‐Maeso, Pedro R. Cutillas, Juan F. López‐Giménez   +7 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Data Sheet 1_PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome.docx

Hua Ma (2443177), Dahe Qi (22229074), Yating Xu (10028264), Tingting Shang (5876615), Yu Si (580933), Wenyue Chen (778397), Hongting Zhao (4479655), Qingling Ren (11051511)   +7 more
openalex   +1 more source