Results 251 to 260 of about 2,310,452 (384)

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging. [PDF]

J Med Virol
Novazzi F, Spezia PG, Ferrante FD, Genoni AP, Grossi PA, Mancini N, Malavolta M, Balietti M, Piacenza F, Marcozzi S, Fortunato C, Badillo Pazmay GV, Cianfruglia L, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Zampieri M, Caiafa P, Ciccarone F, Reale A, Weinberger B, Sikora E, Debacq-Chainiaux F, Stuetz W, Hurme M, Slagboom PE, Bernhardt J, Olivieri F, Filippini F, Maggi F, Giacconi R.   +35 more
europepmc   +1 more source

Author Correction: HMGB1 mediates microbiome-immune axis dysregulation underlying reduced neutralization capacity in obesity-related post-acute sequelae of SARS-CoV-2 [PDF]

Noelle Rubas, Rafael Peres, Braden P. Kunihiro, Nina Allan, Krit Phankitnirundorn, Riley K. Wells, Trevor McCracken, Rosa H. Lee, Lesley Umeda, Andie Conching, Rubén Juárez, Alika K. Maunakea   +11 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

PRMT3 at the crossroads of inflammation: dual roles in metabolic reprogramming and immune dysregulation in chronic diseases. [PDF]

Front Immunol
Hou H, Meng J, Chen Y, Zhang X, Yang Z, Wang Q, Zheng M, Jiang Z.   +7 more
europepmc   +1 more source

Dysregulation of the complement system in immune thrombocytopenia [PDF]

Justin Oosterlee, Nóra Veszeli, Jasmin Rast, Helmuth Haslacher, Cihan Ay, Ingrid Pabinger, Zoltán Prohászka, Johanna Gebhart   +7 more
openalex   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Single-cell transcriptomics reveals systemic immune dysregulation in non-segmental vitiligo. [PDF]

Front Immunol
Xiao J, Guo X, Gong L, Li Q, Dong K, Guo X, Li H, Wang T, Wang L, Wu W, Gan C, Li M, Gong B, Jiang Y, Wu Y, Hu Y, Han L, Yang J, Mao Y.   +18 more
europepmc   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Atopic dermatitis in inborn errors of immunity: at the interface of immunodeficiency and immune dysregulation. [PDF]

Immunol Res
Szczawińska-Popłonyk A.
europepmc   +1 more source

Immune Dysregulation in Patients Persistently Infected with Human Papillomaviruses 6 and 11 [PDF]

, 2015
Alexandra V. Lucs, James A. DeVoti, Lynda Hatam, Ali R. Afzal, Allan L. Abramson, Bettie M. Steinberg, Vincent R. Bonagura   +6 more
openalex   +1 more source