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Distinct Ocular Surface Microbiome in Keratoconus Patients Correlate With Local Immune Dysregulation. [PDF]
Kumar NR+8 more
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Immune dysregulation in atopic dermatitis
Allergy and Asthma Proceedings, 2006Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic, inflammatory skin disease characterized by cutaneous hyperreactivity to environmentals triggers. Recent data suggest the presence of two different forms of AD: an extrinsic AD with elevated IgE involving 70-80% of the patients and an intrinsic AD with serum IgE not elevated and no ...
MIRAGLIA DEL GIUDICE, Michele+7 more
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Asthma: an epidemic of dysregulated immunity [PDF]
The remarkable increase in asthma prevalence that has occurred over the last two decades is thought to be caused by changes in the environment due to improved hygiene and fewer childhood infections. However, the specific infections that limit T helper type 2 (T(H)2)-biased inflammation and asthma are not fully known.
Jennifer J. McIntire+4 more
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Immune dysregulation in asthma
Current Opinion in Immunology, 2006Allergic diseases and asthma are caused by dysregulated Th2-biased immune responses to environmental allergens in genetically predisposed individuals. Over the past several years there has been much progress in understanding the mechanisms by which Th2 responses are generated and the pathogenic role of natural killer T cells in asthma.
Rosemarie H. DeKruyff, Dale T. Umetsu
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Immune dysregulation in atopic dermatitis
Veterinary Immunology and Immunopathology, 2002Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans and dogs with comparable clinical features. Comparative studies of immunological events in the pathogenesis of AD may contribute to understanding of the disease in dogs and to development and evaluation of immunomodulatory strategies of relevance to both species.Both allergen ...
Victor P.M.G. Rutten+2 more
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Genetic disorders with immune dysregulation
Cellular and Molecular Life Sciences, 2011We summarize the clinical presentation and molecular basis of a unique group of congenital immunodeficiency disorders in which defects in immune tolerance mechanisms result in severe autoimmunity. Patients with severe, familial forms of multi-organ autoimmunity have been recognized and clinically described for more than 40 years (Clin Exp Immunol 1 ...
Troy R. Torgerson+2 more
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Psoriasis: dysregulation of innate immunity
British Journal of Dermatology, 2005The current understanding of the function of natural killer (NK) T cells in innate immunity and their potential to control acquired specific immunity, as well as the remarkable efficacy of antitumour necrosis factor-alpha biological treatments in psoriasis, forces us to refine the current T-cell hypothesis of psoriasis pathogenesis, and to give credit ...
Jan D. Bos+3 more
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