Results 271 to 280 of about 215,248 (308)
Some of the next articles are maybe not open access.
An Immune Dysregulation in MPN
Current Hematologic Malignancy Reports, 2014Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid malignancies characterized by a unique somatic mutational profile since three mutually exclusive mutations (JAK2V617F, MPL, and CALR) sustain the great majority of the cases. However, clinical observation that autoimmune diseases may predispose to MPNs, autoimmune disorders or ...
openaire +3 more sources
Immune Dysregulation in Sepsis
Clinical Pediatric Emergency Medicine, 2014The systemic inflammatory response syndrome is a manifestation of the host's immune response to infection. With an aim to eradicate the pathogen, the immune system is activated to encourage a state of inflammation, which is followed by a number of interactions to restore homeostasis.
Michael Kelleher +2 more
openaire +2 more sources
Diseases of Immune Dysregulation
2021Inborn errors of immune regulation are a heterogeneous group of genetic disorders with variable clinical manifestations, including lymphoproliferation, autoimmunity, and increased susceptibility to infections. They are caused by defects in genes involved in controlling when and how the immune system must turn on, which and how much cytokines release ...
openaire +2 more sources
2012
The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or ...
Asghar Aghamohammadi +8 more
openaire +2 more sources
The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or ...
Asghar Aghamohammadi +8 more
openaire +2 more sources
Immune Dysregulation in Atopic Eczema
Archives of Dermatology, 1992In this review, present knowledge of atopic eczema immunopathogenesis is summarized, emphasizing recent new findings. Systemic abnormalities in cell-mediated immunity have not been demonstrated firmly in patients with atopic eczema. Within the skin itself, there is evidence for decreased cell-mediated immunity, which is partially correlated with the ...
Jan D. Bos +4 more
openaire +3 more sources
Cellular immune dysregulation in the pathogenesis of immune thrombocytopenia
Blood Coagulation & Fibrinolysis, 2020Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease characterized by immune-mediated increased platelet destruction and decreased platelet production, resulting from immune intolerance to autoantigen. The pathogenesis of ITP remains unclear, although dysfunction of T and B lymphocytes has been shown to ...
Ruiting Wen +4 more
openaire +3 more sources
Immunodeficiency and disorders of immune dysregulation
Pediatric Allergy and Immunology, 2020AbstractThe spectrum of clinical features associated with primary immune deficiency disorders (PIDs) has broadened due to the recent identification of many novel causative genes. Patients present with increased susceptibility to infections in addition to significant immune dysregulation, often leading to multiple autoimmunity, lymphoproliferation, and ...
openaire +3 more sources
Current Opinion in Allergy and Clinical Immunology, 2002
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a fatal syndrome of overwhelming autoimmunity. Recent identification of FOXP3 as the causative gene and realization that this same gene defect occurs in the mutant mouse Scurfy has yielded new insights and hopes of unraveling the mechanism of autoimmunity in this and possibly ...
Troy R. Torgerson, Hans D. Ochs
openaire +3 more sources
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a fatal syndrome of overwhelming autoimmunity. Recent identification of FOXP3 as the causative gene and realization that this same gene defect occurs in the mutant mouse Scurfy has yielded new insights and hopes of unraveling the mechanism of autoimmunity in this and possibly ...
Troy R. Torgerson, Hans D. Ochs
openaire +3 more sources
Asthma: The importance of dysregulated barrier immunity
European Journal of Immunology, 2013Chronic asthma is an inflammatory disease of the airway wall that leads to bronchial smooth muscle hyperreactivity and airway obstruction, caused by inflammation, goblet cell metaplasia, and airway wall remodeling. In response to allergen presentation by airway DCs, T‐helper lymphocytes of the adaptive immune system control many aspects of the disease ...
Bart N. Lambrecht, Hamida Hammad
openaire +4 more sources
MRI investigation of immune dysregulation in schizophrenia
Current Opinion in Psychiatry, 2019Immune dysregulation has been suggested as a pathophysiological pathway in schizophrenia. MRI could aid in investigating this pathological process in more detail. This review aims to provide an overview of recent MRI findings of immune dysregulation in schizophrenia. In addition, we discuss the potential of more recently developed MRI techniques.Subtle
René C.W. Mandl +4 more
openaire +4 more sources