Results 271 to 280 of about 2,310,452 (384)

The regulatory mechanisms and treatment of HDAC6 in immune dysregulation diseases. [PDF]

Front Immunol
Liang Y, Wang Y, Xing J, Li J, Zhang K.
europepmc   +1 more source

Dissecting immune regulation and dysregulation in autoimmune diabetes from the vantage point of the target tissue

, 2013
Ashley E. Mahne
openalex   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

IL-12 as a Potential Prognostic Marker in Penile Cancer: Implications for Immune Dysregulation. [PDF]

Int J Mol Sci
Czajkowski M, Kunc M, Kieżun J, Kraziński BE, Matuszewski M, Łyzińska W, Hakenberg OW, Wierzbicki PM.   +7 more
europepmc   +1 more source

Image 1_Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma.tif

Yibo Xia (9293844), Dong Zheng (102852), Xinyi Zhang (36040), Shuxia Zhu (21097262), Enqing Lan (21097274), Hansen Ying (21097280), Zixing Chen (345940), Bingxin Zhang (13011397), Shujuan Zhou (15325297), Yu Zhang (12946), Xuanru Lin (15325300), Qiang Zhuang (395174), Honglan Qian (15325306), Xudong Hu (354241), Yan Zhuang (115199), Qianying Zhang (2391760), Xiangjing Zhou (721219), Zuoting Xie (721213), Songfu Jiang (788004), Yongyong Ma (545502), Zhouxiang Jin (15325309), Sisi Zheng (1574473)   +21 more
openalex   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Th17-related cytokines and chemokines are associated with immune dysregulation and severity in schizophrenia. [PDF]

Front Psychiatry
Liang H, Xu J.
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP-CD74 signaling and CXCL1 as diagnostic biomarkers. [PDF]

Front Immunol
He S, Ma F, Yu M, Wu JM, Gong YM, Luo KW, Chang H, Liang Q, Ning Y.   +8 more
europepmc   +1 more source