Results 271 to 280 of about 236,691 (313)
Some of the next articles are maybe not open access.
Immune dysregulation in asthma
Current Opinion in Immunology, 2006Allergic diseases and asthma are caused by dysregulated Th2-biased immune responses to environmental allergens in genetically predisposed individuals. Over the past several years there has been much progress in understanding the mechanisms by which Th2 responses are generated and the pathogenic role of natural killer T cells in asthma.
Rosemarie H. DeKruyff, Dale T. Umetsu
openaire +3 more sources
Immune dysregulation in atopic dermatitis
Veterinary Immunology and Immunopathology, 2002Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans and dogs with comparable clinical features. Comparative studies of immunological events in the pathogenesis of AD may contribute to understanding of the disease in dogs and to development and evaluation of immunomodulatory strategies of relevance to both species.Both allergen ...
Victor P.M.G. Rutten +2 more
openaire +4 more sources
Genetic disorders with immune dysregulation
Cellular and Molecular Life Sciences, 2011We summarize the clinical presentation and molecular basis of a unique group of congenital immunodeficiency disorders in which defects in immune tolerance mechanisms result in severe autoimmunity. Patients with severe, familial forms of multi-organ autoimmunity have been recognized and clinically described for more than 40 years (Clin Exp Immunol 1 ...
Troy R. Torgerson +2 more
openaire +3 more sources
Immune Dysregulation in Sepsis
Clinical Pediatric Emergency Medicine, 2014The systemic inflammatory response syndrome is a manifestation of the host's immune response to infection. With an aim to eradicate the pathogen, the immune system is activated to encourage a state of inflammation, which is followed by a number of interactions to restore homeostasis.
Michael Kelleher +2 more
openaire +2 more sources
An Immune Dysregulation in MPN
Current Hematologic Malignancy Reports, 2014Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid malignancies characterized by a unique somatic mutational profile since three mutually exclusive mutations (JAK2V617F, MPL, and CALR) sustain the great majority of the cases. However, clinical observation that autoimmune diseases may predispose to MPNs, autoimmune disorders or ...
openaire +3 more sources
Psoriasis: dysregulation of innate immunity
British Journal of Dermatology, 2005The current understanding of the function of natural killer (NK) T cells in innate immunity and their potential to control acquired specific immunity, as well as the remarkable efficacy of antitumour necrosis factor-alpha biological treatments in psoriasis, forces us to refine the current T-cell hypothesis of psoriasis pathogenesis, and to give credit ...
Jan D. Bos +3 more
openaire +3 more sources
Diseases of Immune Dysregulation
2021Inborn errors of immune regulation are a heterogeneous group of genetic disorders with variable clinical manifestations, including lymphoproliferation, autoimmunity, and increased susceptibility to infections. They are caused by defects in genes involved in controlling when and how the immune system must turn on, which and how much cytokines release ...
openaire +2 more sources
Immune Dysregulation in Atopic Eczema
Archives of Dermatology, 1992In this review, present knowledge of atopic eczema immunopathogenesis is summarized, emphasizing recent new findings. Systemic abnormalities in cell-mediated immunity have not been demonstrated firmly in patients with atopic eczema. Within the skin itself, there is evidence for decreased cell-mediated immunity, which is partially correlated with the ...
Jan D. Bos +4 more
openaire +3 more sources
2012
The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or ...
Asghar Aghamohammadi +8 more
openaire +2 more sources
The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or ...
Asghar Aghamohammadi +8 more
openaire +2 more sources
Cellular immune dysregulation in the pathogenesis of immune thrombocytopenia
Blood Coagulation & Fibrinolysis, 2020Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease characterized by immune-mediated increased platelet destruction and decreased platelet production, resulting from immune intolerance to autoantigen. The pathogenesis of ITP remains unclear, although dysfunction of T and B lymphocytes has been shown to ...
Ruiting Wen +4 more
openaire +3 more sources