Results 21 to 30 of about 316,804 (365)

Immune Dysregulation in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. A shift toward Th1 and possibly Th17 cells together with impaired regulatory compartment, including T-regulatory (Tregs) and B-regulatory (Bregs) cells, have ...
Weili Bao, Karina Yazdanbakhsh, Hui Zhong   +2 more
openaire   +3 more sources

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications

Frontiers in Immunology, 2023
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis (Option B+) has dramatically improved the health of HIV-infected women and their children, with the majority being of HIV-exposed children born uninfected (HEU).
Hope Mataramvura, Madeleine J. Bunders, Madeleine J. Bunders, Kerina Duri   +3 more
doaj   +1 more source

Immune Dysregulation in Acute SARS-CoV-2 Infection

Pathogens and Immunity, 2023
Introduction: Neutralizing antibodies have been shown to develop rapidly following SARS-CoV-2 infection, specifically against spike (S) protein, where cytokine release and production is understood to drive the humoral immune response during acute ...
Lauren Grimm, Chinyere Onyeukwu, Grace Kenny, Danielle Parent, Jia Fu, Shaurya Dhingra, Emily Yang, James Moy, PJ Utz, Russell Tracy, Alan Landay   +10 more
doaj   +1 more source

Immune Dysregulation in Pediatric Common Variable Immunodeficiency: Implications for the Diagnostic Approach

Frontiers in Pediatrics, 2022
Infections and infectious complications are hallmarks of common variable immunodeficiency (CVID) and the leading cause of morbidity and mortality in affected patients at any age.
Aleksandra Szczawińska-Popłonyk, Katarzyna Ta̧polska-Jóźwiak, Eyal Schwartzmann, Natalia Popłonyk   +3 more
doaj   +1 more source

Depression, dementia and immune dysregulation [PDF]

Brain, 2020
AbstractMajor depression is a prevalent illness that increases the risk of several neurological conditions. These include stroke, cardiovascular disease, and dementia including Alzheimer’s disease. In this review we ask whether certain types of depression and associated loneliness may be a harbinger of cognitive decline and possibly even dementia.
Shawn Hayley, Antoine M Hakim, Paul R Albert   +2 more
openaire   +3 more sources

EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEM

Anti-Aging Eastern Europe, 2023
Immunosenescence or aging of the immune system is characterized by dysregulation of the innate and adaptive immune system mechanisms, associated with a systemic low-grade inflammation (i.e., «inflammaging»), non-effective protective humoral and cellular ...
Dimitrina Miteva, Tsvetelina Velikova
doaj   +1 more source

Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey. [PDF]

, 2020
Primary Immune Regulatory Disorders (PIRD) are an expanding group of diseases caused by gene defects in several different immune pathways, such as regulatory T cell function.
Allenspach, Eric J, Andolina, Jeffrey R, Aquino, Victor M, Bacchetta, Rosa, Bednarski, Jeffrey J, Bhatia, Monica, Buckley, Rebecca H, Burroughs, Lauri M, Caywood, Emi, Chan, Alice Y, Chandrakasan, Shanmuganathan, Chellapandian, Deepak, Chen, Karin, Chong, Hey, Cooper, Megan A, Cowan, Morton J, Craddock, John A, Cuvelier, Geoffrey DE, Davila Saldana, Blachy J, de la Morena, Maria Teresa, Dorsey, Morna J, Dvorak, Christopher C, Forbes, Lisa R, Gennery, Andrew R, Goldman, Frederick D, Griffith, Linda M, Haddad, Elie, Heimall, Jennifer, Jordan, Michael B, Kapoor, Neena, Kohn, Donald B, Leiding, Jennifer W, Liu, Xuerong, Logan, Brent R, Marsh, Rebecca A, Martinez, Caridad, Meyts, Isabelle, Miller, Holly K, Notarangelo, Luigi D, Oshrine, Benjamin R, Pai, Sung-Yun, Parikh, Suhag, Prockop, Susan E, Puck, Jennifer M, Pulsipher, Michael A, Seidel, Markus G, Seroogy, Christine M, Shenoy, Shalini, Shereck, Evan, Shyr, David C, Skoda-Smith, Suzanne, Slatter, Mary, Smith, Angela R, Sullivan, Kathleen E, Torgerson, Troy R, Uzel, Gulbu, Vander Lugt, Mark T, Walter, Jolan E, Weinacht, Katja G, Wright, Nicola   +59 more
core   +1 more source

Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine

Frontiers in Immunology, 2020
Objective: To assess the efficiency of the endometrial immune profiling as a method to design personalized care to enhance the pregnancy rate in a large heterogeneous infertile population.
Nathalie Lédée, Nathalie Lédée, Marie Petitbarat, Laura Prat-Ellenberg, Géraldine Dray, Guy N. Cassuto, Guy N. Cassuto, Lucie Chevrier, Alaa Kazhalawi, Katia Vezmar, Gerard Chaouat   +10 more
doaj   +1 more source

A nonconservative kinetic model under the action of an external force field for modeling the medical treatment of autoimmune response [PDF]

, 2023
In this paper, we develop a new nonconservative kinetic framework to be applied for the study of immune system dysregulation. From the modeling viewpoint, the new kinetic model regards a system, composed of stochastically interacting agents, under the action of an eternal force field.
arxiv   +1 more source

Lentivirus-induced immune dysregulation [PDF]

Veterinary Immunology and Immunopathology, 2008
FIV/HIV infections are associated with an early robust humoral and cellular anti-viral immune response followed by a progressive immune suppression that eventually results in AIDS. Several mechanisms responsible for this immune dysfunction have been proposed including cytokine dysregulation, immunologic anergy and apoptosis, and inappropriate ...
Mary B. Tompkins, Wayne A. F. Tompkins
openaire   +2 more sources