Results 21 to 30 of about 2,310,452 (384)

Immune Dysregulation in Immune Thrombocytopenia [PDF]

Seminars in Hematology, 2013
Immune thrombocytopenia (ITP) is a bleeding disorder characterized by low platelet counts due to decreased platelet production as well as increased platelet destruction by autoimmune mechanisms. A shift toward Th1 and possibly Th17 cells together with impaired regulatory compartment, including T-regulatory (Tregs) and B-regulatory (Bregs) cells, have ...
Karina, Yazdanbakhsh, Hui, Zhong, Weili, Bao   +2 more
openaire   +2 more sources

Lentivirus-induced immune dysregulation [PDF]

Veterinary Immunology and Immunopathology, 2008
FIV/HIV infections are associated with an early robust humoral and cellular anti-viral immune response followed by a progressive immune suppression that eventually results in AIDS. Several mechanisms responsible for this immune dysfunction have been proposed including cytokine dysregulation, immunologic anergy and apoptosis, and inappropriate ...
Mary B, Tompkins, Wayne A, Tompkins
openaire   +2 more sources

Dysregulation of immune response in patients with COVID-19 in Wuhan, China

Clinical Infectious Diseases, 2020
Background In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China. Methods Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February ...
C. Qin, Luo-Qi Zhou, Zi-Wei Hu, Shuoqi Zhang, Sheng Yang, Yu Tao, Cuihong Xie, K. Ma, Ke Shang, Wei Wang, Daishi Tian   +10 more
semanticscholar   +1 more source

Depression, dementia and immune dysregulation [PDF]

Brain, 2020
AbstractMajor depression is a prevalent illness that increases the risk of several neurological conditions. These include stroke, cardiovascular disease, and dementia including Alzheimer’s disease. In this review we ask whether certain types of depression and associated loneliness may be a harbinger of cognitive decline and possibly even dementia.
Shawn Hayley, Antoine M Hakim, Paul R Albert   +2 more
openaire   +2 more sources

Immune dysregulation in sepsis: experiences, lessons and perspectives

Cell Death Discovery, 2023
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious hazard to human health, but it also imposes a substantial economic burden on the healthcare system.
Min Cao, Guozheng Wang, Jianfeng Xie
semanticscholar   +1 more source

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications

Frontiers in Immunology, 2023
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis (Option B+) has dramatically improved the health of HIV-infected women and their children, with the majority being of HIV-exposed children born uninfected (HEU).
Hope Mataramvura, Madeleine J. Bunders, Madeleine J. Bunders, Kerina Duri   +3 more
doaj   +1 more source

A consensus immune dysregulation framework for sepsis and critical illnesses. [PDF]

Nat Med
Moore AR, Zheng H, Ganesan A, Hasin-Brumshtein Y, Maddali MV, Levitt JE, van der Poll T, Lu J, Bouma HR, Scicluna BP, Giamarellos-Bourboulis EJ, Kotsaki A, Martin-Loeches I, Garduno A, Hinson J, Rothman RE, Sevransky J, Wright DW, Atreya MR, Moldawer LL, Efron PA, Kralovcova M, Karvunidis T, Giannini HM, Meyer NJ, Sweeney TE, Rogers AJ, Khatri P.   +27 more
europepmc   +3 more sources

Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion

Science Advances, 2023
Prolonged cytopenias after chimeric antigen receptor (CAR) T cell therapy are a significant clinical problem and the underlying pathophysiology remains poorly understood.
K. Rejeski, A. Perez, G. Iacoboni, V. Blumenberg, V. Bücklein, S. Völkl, O. Penack, O. Albanyan, S. Stock, Fabian Müller, P. Karschnia, A. Petrera, Kayla Reid, R. Faramand, M. Davila, Karnav Modi, Erin A. Dean, C. Bachmeier, Michael von Bergwelt-Baildon, F. Locke, W. Bethge, L. Bullinger, A. Mackensen, P. Barba, M. Jain, M. Subklewe   +25 more
semanticscholar   +1 more source

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?

Nature reviews. Immunology, 2021
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds to acute respiratory distress syndrome and death. Three highly pathogenic human coronaviruses — severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East ...
L. Wong, S. Perlman
semanticscholar   +2 more sources

Immune dysregulation in multiple myeloma: the current and future role of cell-based immunotherapy

International journal of hematology, 2023
Immune dysregulation is a hallmark of clinically active multiple myeloma (MM). Interactions between malignant clonal cells and immune cells within the bone marrow microenvironment are associated with the formation of a milieu favorable to tumor ...
B. Russell, D. Avigan
semanticscholar   +1 more source