Results 21 to 30 of about 333,732 (368)

Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
BackgroundSystemic immune dysregulation correlates with cancer progression. However, the clinical implications of systemic immune dysregulation in early non-small cell lung cancer (NSCLC) remain unclear.MethodsUsing a panel of 9 markers to identify 12 ...
Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Feng Du, Zhongwei Xin, Zhongwei Xin, Dang Wu, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Shenghang Jin, Pin Wu, Pin Wu   +21 more
doaj   +1 more source

The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification

Frontiers in Immunology, 2022
Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal diseases with diverse clinical courses, and immune dysregulation plays an important role in the pathogenesis of MDS.
Xiaohuan Peng, Xiaohuan Peng, Xiaofeng Zhu, Xiaofeng Zhu, Tianning Di, Tianning Di, Futian Tang, Xiaojia Guo, Yang Liu, Jun Bai, Yanhong Li, Lijuan Li, Lijuan Li, Liansheng Zhang, Liansheng Zhang   +14 more
doaj   +1 more source

Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction

Nature Communications, 2021
Multi-inflammatory syndrome in children (MIS-C) can be associated with SARS-CoV-2 infection but can also be similar to other inflammatory syndromes. Here the authors characterise the plasma proteome phenotype in MIS-C and compare to other SARS-CoV-2 ...
Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens   +19 more
doaj   +1 more source

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications

Frontiers in Immunology, 2023
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis (Option B+) has dramatically improved the health of HIV-infected women and their children, with the majority being of HIV-exposed children born uninfected (HEU).
Hope Mataramvura, Madeleine J. Bunders, Madeleine J. Bunders, Kerina Duri   +3 more
doaj   +1 more source

Immune Dysregulation in Acute SARS-CoV-2 Infection

Pathogens and Immunity, 2023
Introduction: Neutralizing antibodies have been shown to develop rapidly following SARS-CoV-2 infection, specifically against spike (S) protein, where cytokine release and production is understood to drive the humoral immune response during acute ...
Lauren Grimm, Chinyere Onyeukwu, Grace Kenny, Danielle Parent, Jia Fu, Shaurya Dhingra, Emily Yang, James Moy, PJ Utz, Russell Tracy, Alan Landay   +10 more
doaj   +1 more source

Immune Dysregulation in Pediatric Common Variable Immunodeficiency: Implications for the Diagnostic Approach

Frontiers in Pediatrics, 2022
Infections and infectious complications are hallmarks of common variable immunodeficiency (CVID) and the leading cause of morbidity and mortality in affected patients at any age.
Aleksandra Szczawińska-Popłonyk, Katarzyna Ta̧polska-Jóźwiak, Eyal Schwartzmann, Natalia Popłonyk   +3 more
doaj   +1 more source

Microvascular significance of TGF-β axis activation in COVID-19

Frontiers in Cardiovascular Medicine, 2023
As 2023 approaches, the COVID-19 pandemic has killed millions. While vaccines have been a crucial intervention, only a few effective medications exist for prevention and treatment of COVID-19 in breakthrough cases or in unvaccinated or immunocompromised ...
Lauren M. Arguinchona, Caterina Zagona-Prizio, Megan E. Joyce, Edward D. Chan, Edward D. Chan, Edward D. Chan, James P. Maloney   +6 more
doaj   +1 more source

Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine

Frontiers in Immunology, 2020
Objective: To assess the efficiency of the endometrial immune profiling as a method to design personalized care to enhance the pregnancy rate in a large heterogeneous infertile population.
Nathalie Lédée, Nathalie Lédée, Marie Petitbarat, Laura Prat-Ellenberg, Géraldine Dray, Guy N. Cassuto, Guy N. Cassuto, Lucie Chevrier, Alaa Kazhalawi, Katia Vezmar, Gerard Chaouat   +10 more
doaj   +1 more source

EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEM

Anti-Aging Eastern Europe, 2023
Immunosenescence or aging of the immune system is characterized by dysregulation of the innate and adaptive immune system mechanisms, associated with a systemic low-grade inflammation (i.e., «inflammaging»), non-effective protective humoral and cellular ...
Dimitrina Miteva, Tsvetelina Velikova
doaj   +1 more source

A nonconservative kinetic model under the action of an external force field for modeling the medical treatment of autoimmune response [PDF]

, 2023
In this paper, we develop a new nonconservative kinetic framework to be applied for the study of immune system dysregulation. From the modeling viewpoint, the new kinetic model regards a system, composed of stochastically interacting agents, under the action of an eternal force field.
arxiv   +1 more source