Results 311 to 320 of about 2,310,452 (384)

The role of immune dysregulation in the pathogenesis of type 1 diabetes: a paradigm shift in prevention strategies

EXCLI Journal : Experimental and Clinical Sciences
Rajiv Gandhi Gopalsamy, Hariharan Govindasamy, Jessiane Bispo de Souza, Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Ronaldy Santana Santos, Marina dos Santos Barreto, Adriana Gibara Guimarães, Lucas Alves da Mota Santana, Lysandro Pinto Borges, Eloia Emanuelly Dias Silva   +10 more
doaj   +1 more source

When the victim becomes the villain: Platelets as drivers of immune dysregulation in ITP. [PDF]

J Transl Autoimmun
Farhid F, Rezaeeyan H, Habibi R, Kamali Yazdi E, Hamblin MR, Naghinezhad J.   +5 more
europepmc   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Computational Identification of RNF114 nsSNPs with Potential Roles in Psoriasis and Immune Dysregulation. [PDF]

Med Sci (Basel)
Aldoseri GM, Alwabran AI, Aldoseri GM, Aldoseri MM, Kamal E.   +4 more
europepmc   +1 more source

Table 1_Early-life undernutrition, immune dysregulation, and cancer incidence in later life: a national life-course analysis from the China health and retirement longitudinal study.docx

Hailin Wang (67695), Changkang Wu (22130089), Xuancheng Zhou (17986102), Gang Huang (136671), Jingdong Li (9227564), Xiaowei Tang (410415)   +5 more
openalex   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Oral and Periodontal Health Status, Peripheral Immune Dysregulation, and Cognitive Impairment in Alzheimer's Disease: A Clinical and Immunological Study. [PDF]

Int J Mol Sci
Ochnik M, Zborowski J, Leszek J, Senczyszyn A, Diniz BS, Sender-Janeczek A, Piasecki E, Sochocka M.   +7 more
europepmc   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Periodontitis Salivary Microbiota Exacerbates Murine Rheumatoid Arthritis via Gut Dysbiosis and Immune Dysregulation. [PDF]

FASEB J
Ge R, Liu R, Zhou Y, Zhuang Z, Mao H, Liao W, Han L, Yang W, Yan F, Cui D.   +9 more
europepmc   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source