Results 331 to 340 of about 2,310,452 (384)

IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation

Science immunology, 2023
The ability of most patients with selective immunoglobulin A (IgA) deficiency (SIgAD) to remain apparently healthy has been a persistent clinical conundrum.
Peyton E. Conrey, Lidiya Denu, Kaitlin C. O’Boyle, Isaiah Rozich, Jamal Green, Jeffrey R. Maslanka, Jean-Bernard Lubin, Tereza Duranova, Brittany L. Haltzman, Lauren Gianchetti, D. Oldridge, Nina De Luna, L. Vella, D. Allman, J. Spergel, Ceylan Tanes, K. Bittinger, S. Henrickson, Michael A. Silverman   +18 more
semanticscholar   +1 more source

Immune dysregulation in asthma

Current Opinion in Immunology, 2006
Allergic diseases and asthma are caused by dysregulated Th2-biased immune responses to environmental allergens in genetically predisposed individuals. Over the past several years there has been much progress in understanding the mechanisms by which Th2 responses are generated and the pathogenic role of natural killer T cells in asthma.
Dale T, Umetsu, Rosemarie H, Dekruyff
openaire   +2 more sources

Immune dysregulation in atopic dermatitis

Current Allergy and Asthma Reports, 2006
Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions.
Peck Y, Ong, Donald Y M, Leung
openaire   +6 more sources

Immune dysregulation in atopic dermatitis

Veterinary Immunology and Immunopathology, 2002
Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans and dogs with comparable clinical features. Comparative studies of immunological events in the pathogenesis of AD may contribute to understanding of the disease in dogs and to development and evaluation of immunomodulatory strategies of relevance to both species.Both allergen ...
Sinke, J.D., Rutten, V.P.M.G., Willemse, T.   +2 more
openaire   +4 more sources

Psoriasis: dysregulation of innate immunity

British Journal of Dermatology, 2005
The current understanding of the function of natural killer (NK) T cells in innate immunity and their potential to control acquired specific immunity, as well as the remarkable efficacy of antitumour necrosis factor-alpha biological treatments in psoriasis, forces us to refine the current T-cell hypothesis of psoriasis pathogenesis, and to give credit ...
J D, Bos, M A, de Rie, M B M, Teunissen, G, Piskin   +3 more
openaire   +2 more sources

Immune dysregulation and RNA N6‐methyladenosine modification in sepsis

Wiley Interdisciplinary Reviews - RNA, 2022
Sepsis is defined as life‐threatening organ dysfunction caused by the host immune dysregulation to infection. It is a highly heterogeneous syndrome with complex pathophysiological mechanisms.
Hongyan Chen, Xiaoting Zhang, Hao Su, Judeng Zeng, H. Chan, Qing Li, Xiaodong Liu, Lin Zhang, W. Wu, M. T. Chan, Huarong Chen   +10 more
semanticscholar   +1 more source

Diabetic Foot Ulcers: Pathophysiology, Immune Dysregulation, and Emerging Therapeutic Strategies

Biomedicines
Diabetic foot ulcers (DFUs) are among the most common and debilitating complications of diabetes mellitus (DM), affecting approximately 15–25% of patients and contributing to over 85% of non-traumatic amputations.
John Dawi, Kevin Tumanyan, Kirakos Tomas, Yura Misakyan, Areg Gargaloyan, Edgar Gonzalez, Mary Hammi, Serly Tomas, V. Venketaraman   +8 more
semanticscholar   +1 more source

Diseases of immune dysregulation

2021
Inborn errors of immune regulation are a heterogeneous group of genetic disorders with variable clinical manifestations, including lymphoproliferation, autoimmunity, and increased susceptibility to infections. They are caused by defects in genes involved in controlling when and how the immune system must turn on, which and how much cytokines release ...
Hassan Abolhassani, Abbas Dabbaghzadeh, Hamid Ahanchian, Negar Khalighi, Javad Ghaffari, Mohammad Ehlayel, Teresa Espanol, Romina Dieli Crimi, Pilar Llobet Agulló, Tim Niehues   +9 more
openaire   +2 more sources

Interplay Between Insulin Resistance and Immune Dysregulation in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions

ImmunoTargets and Therapy
Type 2 Diabetes Mellitus (T2DM) is a rapidly growing global health issue characterized by insulin resistance and chronic inflammation. Beyond regulating glucose homeostasis, insulin plays a pivotal role in modulating immune cell function, linking ...
Afiat Berbudi, Shafia Khairani, Adi Tjahjadi   +2 more
semanticscholar   +1 more source

Genetic disorders with immune dysregulation

Cellular and Molecular Life Sciences, 2011
We summarize the clinical presentation and molecular basis of a unique group of congenital immunodeficiency disorders in which defects in immune tolerance mechanisms result in severe autoimmunity. Patients with severe, familial forms of multi-organ autoimmunity have been recognized and clinically described for more than 40 years (Clin Exp Immunol 1 ...
GAMBINERI, ELEONORA, Torgerson TR
openaire   +3 more sources