Results 341 to 350 of about 2,310,452 (384)
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2012
The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or ...
Shinsaku Imashuku +8 more
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The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or ...
Shinsaku Imashuku +8 more
openaire +1 more source
An Immune Dysregulation in MPN
Current Hematologic Malignancy Reports, 2014Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid malignancies characterized by a unique somatic mutational profile since three mutually exclusive mutations (JAK2V617F, MPL, and CALR) sustain the great majority of the cases. However, clinical observation that autoimmune diseases may predispose to MPNs, autoimmune disorders or ...
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Immune Dysregulation in Chronic Obstructive Pulmonary Disease
Immunological InvestigationsChronic obstructive pulmonary disease (COPD) is a disease whose incidence increase with age and is characterised by chronic inflammation and significant immune dysregulation.
Xichen Pang, Xiao-Ju Liu
semanticscholar +1 more source
Current Opinion in Allergy and Clinical Immunology, 2002
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a fatal syndrome of overwhelming autoimmunity. Recent identification of FOXP3 as the causative gene and realization that this same gene defect occurs in the mutant mouse Scurfy has yielded new insights and hopes of unraveling the mechanism of autoimmunity in this and possibly ...
Troy R, Torgerson, Hans D, Ochs
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Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a fatal syndrome of overwhelming autoimmunity. Recent identification of FOXP3 as the causative gene and realization that this same gene defect occurs in the mutant mouse Scurfy has yielded new insights and hopes of unraveling the mechanism of autoimmunity in this and possibly ...
Troy R, Torgerson, Hans D, Ochs
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Immune Dysregulation in Sepsis
Clinical Pediatric Emergency Medicine, 2014The systemic inflammatory response syndrome is a manifestation of the host's immune response to infection. With an aim to eradicate the pathogen, the immune system is activated to encourage a state of inflammation, which is followed by a number of interactions to restore homeostasis.
Marcelo Malakooti +2 more
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Targeting Immune Dysregulation in Myelodysplastic Syndromes
JAMA, 2011Myelodysplastic syndromes (MDS) are a heterogeneous group of bone marrow disorders characterized by ineffective hematopoiesis and a tendency to develop leukemia. In some patients, laboratory and clinical evidence supports a role for the immune system in the pathogenesis of early MDS.
Matthew J, Olnes, Elaine M, Sloand
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Overcoming Immune Dysregulation with Immunoengineered Nanobiomaterials
Annual Review of Biomedical Engineering, 2017The immune system is governed by an immensely complex network of cells and both intracellular and extracellular molecular factors. It must respond to an ever-growing number of biochemical and biophysical inputs by eliciting appropriate and specific responses in order to maintain homeostasis.
Evan A, Scott +2 more
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Asthma: an epidemic of dysregulated immunity
Nature Immunology, 2002The remarkable increase in asthma prevalence that has occurred over the last two decades is thought to be caused by changes in the environment due to improved hygiene and fewer childhood infections. However, the specific infections that limit T helper type 2 (T(H)2)-biased inflammation and asthma are not fully known.
Dale T, Umetsu +4 more
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Celiac Disease: An Immune Dysregulation Syndrome
Current Problems in Pediatric and Adolescent Health Care, 2014Celiac disease is a chronic immune-mediated condition that develops in genetically predisposed individuals. It is characterized by the presence of circulating auto-antibodies in addition to an enteropathy and at times, other extra-intestinal manifestations triggered by exposure to the gliadin fraction of gluten, a family of proteins found in wheat ...
Joseph, Levy +2 more
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HIV-Specific Immune Dysregulation and Atherosclerosis
Current HIV/AIDS Reports, 2012HIV + patients face a heightened risk of cardiovascular disease (CVD), which cannot be fully explained by traditional risk factors or antiretroviral therapy (ART)-related cardiotoxicity. Increasing evidence suggests a significant contribution of HIV-specific immune dysregulation to atherosclerosis.
Markella V, Zanni, Steven K, Grinspoon
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