Microvascular significance of TGF-β axis activation in COVID-19
Frontiers in Cardiovascular Medicine, 2023 As 2023 approaches, the COVID-19 pandemic has killed millions. While vaccines have been a crucial intervention, only a few effective medications exist for prevention and treatment of COVID-19 in breakthrough cases or in unvaccinated or immunocompromised ...
Lauren M. Arguinchona +6 more
doaj +1 more source
Fresh Insights into Disease Etiology and the Role of Microbial Pathogens. [PDF]
, 2016 Pathogens have been implicated in the initiation and/or promotion of systemic sclerosis (scleroderma, SSc); however, no evidence was found to substantiate the direct contribution to this disease in past years.
FARINA, Antonella, Farina, G.a.2.
core +1 more source
The Landscape of Long Non-Coding RNA Dysregulation and Clinical Relevance in Muscle Invasive Bladder Urothelial Carcinoma. [PDF]
, 2019 Bladder cancer is one of the most common cancers in the United States, but few advancements in treatment options have occurred in the past few decades.
Chang, Eric Y +7 more
core +1 more source
Dysregulation of Systemic Immunity in Aging and Dementia [PDF]
Frontiers in Cellular Neuroscience, 2021 Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and contribute to neurodegenerative pathology. Although microglia have been the focus of work linking neuroinflammation and associated dementias like Alzheimer’s Disease, the inflammatory milieu of brain is a conglomerate of cross-talk amongst microglia, systemic ...
Jenny Lutshumba +7 more
openaire +4 more sources
Glyphosate induces immune dysregulation in honey bees
Animal Microbiome, 2022 Background Similar to many other animals, the honey bee Apis mellifera relies on a beneficial gut microbiota for regulation of immune homeostasis. Honey bees exposed to agrochemicals, such as the herbicide glyphosate or antibiotics, usually exhibit ...
Erick V. S. Motta +2 more
doaj +1 more source
Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders. [PDF]
, 2015 BackgroundAutism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound ...
Ander, Bradley P +4 more
core +1 more source
Dysregulation of immune response in otitis media [PDF]
Expert Reviews in Molecular Medicine, 2021 Abstract Objective Otitis media (OM) is a common reason for children to be prescribed antibiotics and undergo surgery but a thorough understanding of disease mechanisms is lacking. We evaluate the evidence of a dysregulated immune response in the pathogenesis of OM.
Michael W. Mather +6 more
openaire +3 more sources
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation [PDF]
Transl Respir Med. 2013; 1: 12, 2013 Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic rejection. Novel insights from global gene expression profiles may provide molecular phenotypes and therapeutic targets to improve outcomes after
arxiv +1 more source
miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS. [PDF]
, 2019 ObjectiveOnset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small ...
Aaen, Gregory +31 more
core +5 more sources