Results 31 to 40 of about 217,947 (308)

1731. Immune Dysregulation in Mucormycosis [PDF]

Open Forum Infectious Diseases, 2019
Abstract Background Mucormycosis is a fatal fungal infection with unique predisposition to infect diabetics. Dysregulated adaptive immunity contributes to the pathogenesis in all fungal diseases, but activated Th17 cells have laid a new dimension to chronic inflammatory response which was previously ...
Shukla Das, Praveen Kumar Singh, Mohammad Ahmad Ansari, Gargi Rai, Chhavi Gupta, Sajad Ahmad Dar   +5 more
openaire   +2 more sources

From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review

Diagnostics, 2021
The pathophysiology of myelodysplastic syndromes (MDSs) is complex and often includes immune dysregulation of both the innate and adaptive immune systems.
Thibault Comont, Emmanuel Treiner, François Vergez   +2 more
doaj   +1 more source

The 4th NextGen therapies of SJIA and MAS, part 4: it is time for IL-18 based trials in systemic juvenile idiopathic arthritis?

Pediatric Rheumatology Online Journal
Since IL-18 has recently emerged as a biomarker associated with refractory disease course in SJIA, the focus of the discussion was the feasibility of the biomarker-driven drug development to SJIA. Overall, there was broad agreement on the conclusion that
Scott W. Canna, Fabrizio De Benedetti
doaj   +1 more source

Immune Dysregulation in Obesity

Annual Review of Pathology: Mechanisms of Disease
The immune system plays fundamental roles in maintaining physiological homeostasis. With the increasing prevalence of obesity—a state characterized by chronic inflammation and systemic dyshomeostasis—there is growing scientific and clinical interest in understanding how obesity reshapes immune function.
Zewen, Jiang, Chihiro, Tabuchi, Sarah G, Gayer, Sagar P, Bapat   +3 more
openaire   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Immune Dysregulation in Monogenic Inborn Errors of Immunity in Oman: Over A Decade of Experience From a Single Tertiary Center

Frontiers in Immunology, 2022
BackgroundInborn errors of immunity (IEIs) are being recognized as an important cause of morbidity and mortality in communities with a high frequency of consanguinity, such as Oman, and thus recessively inherited conditions.
Tariq Al Farsi, Khwater Ahmed, Jalila Alshekaili, Mahmood Al Kindi, Matthew Cook, Matthew Cook, Matthew Cook, Aliya Al-Hosni, Zainab Ansari, Iman Nasr, Nashat Al Sukaiti   +10 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Immune dysregulation in primary immune thrombocytopenia patients [PDF]

Hematology, 2018
To explore the immunological abnormalities in patients with primary immune thrombocytopenia (ITP), and analyze its relationship with treatment.Proportion of different immune cell subsets were detected in the peripheral blood of 124 ITP patients at different time points and 45 normal controls by flow cytometry.
Lili Tao, Zhimin Zhai, Fan Wu, Qianshan Tao, Jiyu Wang, Yuanyuan Shen, Can Wu, Xuanxuan Xu, Jeffrey T. Wang, Qiuye Zhang, Jiakui Zhang, Yanjie Ruan, Yiping Wang, Yingwei Li   +13 more
openaire   +3 more sources