Results 31 to 40 of about 236,691 (313)

1731. Immune Dysregulation in Mucormycosis [PDF]

Open Forum Infectious Diseases, 2019
Abstract Background Mucormycosis is a fatal fungal infection with unique predisposition to infect diabetics. Dysregulated adaptive immunity contributes to the pathogenesis in all fungal diseases, but activated Th17 cells have laid a new dimension to chronic inflammatory response which was previously ...
Shukla Das, Praveen Kumar Singh, Mohammad Ahmad Ansari, Gargi Rai, Chhavi Gupta, Sajad Ahmad Dar   +5 more
openaire   +2 more sources

The 4th NextGen therapies of SJIA and MAS, part 4: it is time for IL-18 based trials in systemic juvenile idiopathic arthritis?

Pediatric Rheumatology Online Journal
Since IL-18 has recently emerged as a biomarker associated with refractory disease course in SJIA, the focus of the discussion was the feasibility of the biomarker-driven drug development to SJIA. Overall, there was broad agreement on the conclusion that
Scott W. Canna, Fabrizio De Benedetti
doaj   +1 more source

Immune Dysregulation in Obesity

Annual Review of Pathology: Mechanisms of Disease
The immune system plays fundamental roles in maintaining physiological homeostasis. With the increasing prevalence of obesity—a state characterized by chronic inflammation and systemic dyshomeostasis—there is growing scientific and clinical interest in understanding how obesity reshapes immune function.
Zewen, Jiang, Chihiro, Tabuchi, Sarah G, Gayer, Sagar P, Bapat   +3 more
openaire   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The renal clear cell carcinoma immune landscape

Neoplasia: An International Journal for Oncology Research, 2022
A comprehensive evaluation of the clear cell renal cell carcinoma (ccRCC) immune landscape was found using 584 RNA-sequencing datasets from The Cancer Genome Atlas (TCGA), we identified 17 key dysregulated immune-associated genes in ccRCC based on ...
Omar A. Saad, Wei Tse Li, Aswini R. Krishnan, Griffith C. Nguyen, Jay P. Lopez, Rana R. McKay, Jessica Wang-Rodriguez, Weg M. Ongkeko   +7 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Immune Dysregulation in Monogenic Inborn Errors of Immunity in Oman: Over A Decade of Experience From a Single Tertiary Center

Frontiers in Immunology, 2022
BackgroundInborn errors of immunity (IEIs) are being recognized as an important cause of morbidity and mortality in communities with a high frequency of consanguinity, such as Oman, and thus recessively inherited conditions.
Tariq Al Farsi, Khwater Ahmed, Jalila Alshekaili, Mahmood Al Kindi, Matthew Cook, Matthew Cook, Matthew Cook, Aliya Al-Hosni, Zainab Ansari, Iman Nasr, Nashat Al Sukaiti   +10 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

PTEN Hamartoma Tumor Syndrome and Immune Dysregulation

Translational Oncology, 2019
Carriers of a pathogenic germline mutations in the PTEN gene, a well-known tumor suppressor gene, are at increased risk of multiple benign and malignant tumors, e.g. breast, thyroid, endometrial and colon cancer.
Marc Eissing, Lise Ripken, Gerty Schreibelt, Harm Westdorp, Marjolijn Ligtenberg, Romana Netea-Maier, Mihai G. Netea, I. Jolanda M. de Vries, Nicoline Hoogerbrugge   +8 more
doaj   +1 more source

Down Syndrome and COVID-19: A Perfect Storm?

Cell Reports Medicine, 2020
People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis.
Joaquin M. Espinosa
doaj   +1 more source