Genetics of Immune Dysregulation and Cancer Predisposition: Two Sides of the Same Coin
Clinical and Experimental Immunology, 2022 Approximately 10% of cancers have a hereditary predisposition. However, no genetic diagnosis is available in 60%-80% of familial cancers. In some of these families, immune dysregulation-mediated disease is frequent.
Sigal Matza Porges, O. Shamriz
semanticscholar +1 more source
Dysregulation of Systemic Immunity in Aging and Dementia [PDF]
Frontiers in Cellular Neuroscience, 2021 Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and contribute to neurodegenerative pathology. Although microglia have been the focus of work linking neuroinflammation and associated dementias like Alzheimer’s Disease, the inflammatory milieu of brain is a conglomerate of cross-talk amongst microglia, systemic ...
Jenny Lutshumba +7 more
openaire +4 more sources
Mucosal Immune System Dysregulation in the Pathogenesis of IgA Nephropathy
Biomedicines, 2022 The mucosal immune system, via a dynamic immune network, serves as the first line of defense against exogenous antigens. Mucosal immune system dysregulation is closely associated with the pathogenesis of immunoglobulin A nephropathy (IgAN), as ...
Toshiki Kano +11 more
doaj +1 more source
Dysregulation of immune response in otitis media [PDF]
Expert Reviews in Molecular Medicine, 2021 Abstract Objective Otitis media (OM) is a common reason for children to be prescribed antibiotics and undergo surgery but a thorough understanding of disease mechanisms is lacking. We evaluate the evidence of a dysregulated immune response in the pathogenesis of OM.
Michael W. Mather +6 more
openaire +3 more sources
MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation [PDF]
Transl Respir Med. 2013; 1: 12, 2013 Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic rejection. Novel insights from global gene expression profiles may provide molecular phenotypes and therapeutic targets to improve outcomes after
arxiv +1 more source
Stratification of Systemic Lupus Erythematosus Patients Using Gene Expression Data to Reveal Expression of Distinct Immune Pathways [PDF]
, 2020 Systemic lupus erythematosus (SLE) is the tenth leading cause of death in females 15-24 years old in the US. The diversity of symptoms and immune pathways expressed in SLE patients causes difficulties in treating SLE as well as in new clinical trials.
arxiv +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Unraveling Post-COVID-19 Immune Dysregulation Using Machine Learning-based Immunophenotyping [PDF]
arXiv, 2023 The COVID-19 pandemic has left a significant mark on global healthcare, with many individuals experiencing lingering symptoms long after recovering from the acute phase of the disease, a condition often referred to as "long COVID." This study delves into the intricate realm of immune dysregulation that ensues in 509 post-COVID-19 patients across ...
arxiv
Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics [PDF]
, 2023 Cancer is a fatal genetic disease involving unregulated cell growth and proliferation with varying underlying complexities including immune evasion, treatment resistance and recurrence, and optimized treatment is required for proper cure. Molecular studies have revealed that tumors are extremely heterogeneous in nature, leading to the complexity of ...
arxiv +1 more source
Communication network model of the immune system identifies the impact of interactions with SARS-CoV-2 proteins [PDF]
arXiv, 2022 Interactions between SARS-CoV-2 and human proteins (SARS-CoV-2 PPIs) cause information transfer through biochemical pathways that contribute to the immunopathology of COVID-19. Here, we present a communication network model of the immune system to compute the information transferred by the viral proteins using the available SARS-CoV-2 PPIs data.
arxiv