Results 91 to 100 of about 1,305,369 (291)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Immune reconstitution efficacy and associated risk factors for immunological non-response in people living with HIV during long-term antiretroviral therapy: a single-center retrospective cohort study at a tertiary care hospital in China

Frontiers in Immunology
Despite sustained virological suppression under antiretroviral therapy (ART), a substantial proportion of people living with HIV (PLWH) fail to achieve adequate immune reconstitution.
Rui Li, Lifeng Liu, Ran Wang, Yuanyi Zhai, Yiming Ren, Wei Hua, Yang Zhang, Lijun Sun, Lili Dai   +8 more
doaj   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Immune Reconstitution Inflammatory Syndrome in children

South African Journal of Radiology, 2017
Immune Reconstitution Inflammatory Syndrome (IRIS) refers to a collection of inflammatorydisorders, predominantly related to infectious processes that manifest after the initiation ofantiretroviral therapy (ART) and can be classified as unmasking or paradoxical. The prevalenceof IRIS in children in sub-Saharan Africa is low.
Mahomed, Nasreen, Reubenson, Gary
openaire   +6 more sources

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

Immune reconstitution after NKI following haplo-SCT.

, 2019
(A) Immune reconstitution after NKI following haplo-SCT in six patients who completed three scheduled NKIs. Median values for cell numbers are presented.
Keon Hee Yoo (7901249), Youngeun Ma (7901246), Yu Kyeong Hwang (8124617), Eun-Suk Kang (814899), Ki Woong Sung (7901252), Hee Won Cho (7901243), Okjae Lim (104000), Hong Hoe Koo (7901255), Miyoung Jung (174459), Meong Hi Son (8124611), Ji Won Lee (306129), Jung Hyun Her (8124614), Young Bae Choi (3119907)   +12 more
core   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Longitudinal immune profiling following autologous hematopoietic stem cell transplantation in multiple sclerosis: insights into immune reconstitution and disease modulation

Frontiers in Immunology
IntroductionAutologous hematopoietic stem cell transplantation (AHSCT) is an effective treatment for relapsing remitting multiple sclerosis, yet the mechanisms underlying immune reset and sustained remission remain incompletely understood.
Malin Müller, Ivan Pavlovic, Anna Wiberg, Joachim Burman   +3 more
doaj   +1 more source