Results 101 to 110 of about 2,306,505 (335)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Cavitation of the Ghon focus in an HIV-infected infant who acquired tuberculosis after the initiation of HAART

Southern African Journal of HIV Medicine, 2009
Tuberculosis immune reconstitution inflammatory syndrome (IRIS) may present as new or worsening cavitation. We present an HIV-infected infant in whom TB infection and subsequent cavitation of the Ghon focus appeared to coincide with immune reconstitution
S. Innes, H. S. Schaaf, M. F. Cotton
doaj   +1 more source

Comparative characteristics of patients presented with unmasking and paradoxical immune-reconstitution syndrome, and patients other than those who presented with unmasking immune-reconstitution syndrome.

, 2016
Comparative characteristics of patients presented with unmasking and paradoxical immune-reconstitution syndrome, and patients other than those who presented with unmasking immune-reconstitution syndrome.
Takahiro Aoki (212477), Tetsuro Kobayashi (308002), Takeshi Nishijima (212471), Yoshimi Kikuchi (212497), Hiroyuki Gatanaga (205448), Katsuji Teruya (212494), Shinichi Oka (205454)   +6 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Borderline tuberculoid leprosy: A manifestation of immune reconstitution inflammatory syndrome in a human immunodeficiency virus infected person

Indian Journal of Dermatology, 2006
Immune reconstitution inflammatory syndrome describes a collection of inflammatory disorders associated with paradoxical deterioration of various pre-existing processes following start of highly active antiretroviral therapy (HAART) in human ...
Mukhopadhyay Partha, Pal Shekhar, Mallik Sudeshna, Biswas Surajit, Saha Bibhuti   +4 more
doaj  

Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition

Medical Mycology Case Reports, 2019
Endemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection.
Theodore Wright, Basak Coruh, David Fredricks, Nina Kim   +3 more
doaj   +1 more source

Antiretroviral Therapy Induces a Rapid Increase in Bone Resorption that is Positively Associated with the Magnitude of Immune Reconstitution in HIV Infection

AIDS (London), 2016
Objective:Antiretroviral therapy (ART) paradoxically intensifies bone loss in the setting of HIV infection. Although the extent of bone loss varies, it occurs with virtually all ART types, suggesting a common pathway that may be aligned with HIV disease ...
Ighoverha Ofotokun, F. Villinger, A. Sheth, Cecile D. Lahiri, Ighovwerha Ofotokun, Aswani Vunnava, S. Roser‐Page, T. Vikulina, Kenneth A. Rogers, J. Lennox, M. Weitzmann   +10 more
semanticscholar   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Immune reconstitution efficacy and associated risk factors for immunological non-response in people living with HIV during long-term antiretroviral therapy: a single-center retrospective cohort study at a tertiary care hospital in China

Frontiers in Immunology
Despite sustained virological suppression under antiretroviral therapy (ART), a substantial proportion of people living with HIV (PLWH) fail to achieve adequate immune reconstitution.
Rui Li, Lifeng Liu, Ran Wang, Yuanyi Zhai, Yiming Ren, Wei Hua, Yang Zhang, Lijun Sun, Lili Dai   +8 more
doaj   +1 more source

The Immunopathogenesis of Cryptococcal Immune Reconstitution Inflammatory Syndrome - Understanding a Conundrum

Current Opinion in Infectious Diseases, 2016
Purpose of review Cryptococcal meningitis causes significant mortality among HIV-infected patients, despite antifungal therapy and use of antiretroviral therapy (ART).
D. Meya, Y. Manabe, D. Boulware, E. Janoff   +3 more
semanticscholar   +1 more source