Results 121 to 130 of about 2,306,505 (335)

Mycobacterium Tuberculosis-Associated Immune Reconstitution Syndrome in Solid-Organ Transplant Recipients

, 2014
Background. Incidence, characteristics, and risk factors for tuberculosis (TB)-associated immune reconstitution inflammatory syndrome (IRS) in solid-organ transplant (SOT) recipients are not known. Methods.
孫幸筠, Sun, Hsin-Yun;Munoz, Patricia;Torre-Cisneros, Julian;Aguado, Jose M.;Lattes, Roberta;Montejo, Miguel;Garcia-Reyne, Ana;Bouza, Emilio;Valerio, Maricela;Lara, Rosario;John, George T.;Bruno, Didier;Singh, Nina   +1 more
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Longitudinal immune profiling following autologous hematopoietic stem cell transplantation in multiple sclerosis: insights into immune reconstitution and disease modulation

Frontiers in Immunology
IntroductionAutologous hematopoietic stem cell transplantation (AHSCT) is an effective treatment for relapsing remitting multiple sclerosis, yet the mechanisms underlying immune reset and sustained remission remain incompletely understood.
Malin Müller, Ivan Pavlovic, Anna Wiberg, Joachim Burman   +3 more
doaj   +1 more source

Paradoxical reactions and immune reconstitution inflammatory syndrome in tuberculosis.

International Journal of Infectious Diseases, 2015
The coalescence of the HIV-1 and tuberculosis (TB) epidemics in Sub-Saharan Africa has had a significant and negative impact on global health.
L. C. Bell, R. Breen, Robert F Miller, M. Noursadeghi, M. Lipman   +4 more
semanticscholar   +1 more source

The immune reconstitution inflammatory syndrome: etiology, pathogenesis, clinical manifestations

, 2019
В умовах поширення захворюваності на ВІЛ-інфекцію у багатьох країнах світу та в Україні, зокрема, пізнього виявлення хворих та збільшення потужності антиретровірусної терапії лікарям усе частіше доводиться зустрічатися із синдромом відновлення імунної ...
Тодоріко, Лілія Дмитрівна, Pentrenko, V.I., Шевченко, О.С., Pohorielova, O.O., Todoriko, L.D., Shevchenko, O.S., Петренко, В.І., Погорєлова, О.О.   +7 more
core   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

The role of graft T-cell size in patients receiving alemtuzumab serotherapy for non-malignant disorders: results of an institutional protocol

Scientific Reports
Although graft T cells assist in engraftment, mediate antiviral immune-reconstitution, and cause graft-versus-host disease, graft size is not determined by T-cell content of the graft.
Ambreen Pandrowala, Sanna Khan, Darshan Kataria, Manasa Kakunje, Varsha Mishra, Dhruv Mamtora, Sangeeta Mudaliar, Minnie Bodhanwala, Bharat Agarwal, Prashant Hiwarkar   +9 more
doaj   +1 more source

HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

Nature Communications, 2015
Patients with HIV-associated tuberculosis (TB) initiating antiretroviral therapy (ART) may develop immune reconstitution inflammatory syndrome (TB-IRIS). No biomarkers for TB-IRIS have been identified and the underlying mechanisms are unclear.
R. Lai, G. Meintjes, K. Wilkinson, C. Graham, S. Marais, H. van der Plas, A. Deffur, C. Schutz, C. Bloom, Indira D Munagala, E. Anguiano, R. Goliath, G. Maartens, J. Banchereau, D. Chaussabel, A. O’Garra, R. Wilkinson   +16 more
semanticscholar   +1 more source

Cellular Immune Reconstitution after Haploidentical Transplantation in Children

, 2007
Delayed immune reconstitution is 1 of the major contributions to the morbidity and mortality after haploidentical transplantation. Patients with a slow recovery of the innate and especially of the adaptive immune system are at high risk for severe and ...
Handgretinger, R., I. Mueller, M. Schumm, P. Lang, Pfeiffer, M., Feuchtinger, T., T. Feuchtinger, Chen, X., Lang, P., Mueller, I., Hale, G., R. Handgretinger, M. Pfeiffer, G. Hale, Schumm, M., X. Chen   +15 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source