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Pathogenesis and Prevention of Immune Reconstitution Disease During Antiretroviral Therapy [PDF]
Expert Review of Anti-Infective Therapy, 2011 The risks of unmasking and paradoxical forms of immune reconstitution disease in HIV-infected patients starting antiretroviral therapy (ART) are fuelled by a combination of the late presentation of patients with advanced immunodeficiency, the associated ...
Graeme Meintjes, Stephen Lawn
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Biology of Blood and Marrow Transplantation, 2019 Immune reconstitution after hematopoietic stem cell transplantation (HSCT) is a complex process. Impacts of the reconstitution of different immune cells over time are complex and difficult to understand.
Jonas Abrahamsson, Karin Mellgren
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Clinics in Laboratory Medicine, 2002
Immune reconstitution in HIV-infected patients remains a potential mechanism to explain delayed disease progression and increased survival following suppressive therapy. Many discrepancies remain to be studied. Is an immune response to HIV protective? Why are anti-HIV CD4 responses lost so quickly in progressors and how can they be restored?
Drew, Weissman, Luis J, Montaner
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Immune reconstitution in HIV-infected patients remains a potential mechanism to explain delayed disease progression and increased survival following suppressive therapy. Many discrepancies remain to be studied. Is an immune response to HIV protective? Why are anti-HIV CD4 responses lost so quickly in progressors and how can they be restored?
Drew, Weissman, Luis J, Montaner
openaire +2 more sources
Cancer, Aging and Immune Reconstitution
Anti-Cancer Agents in Medicinal Chemistry, 2013Aging is a complex phenomenon involving multiple physiological functions. Among these, very important are the modifications induced in the immune system; these modifications may be related to cancer development, a disease of older people. We herein describe the age-dependent alterations observed in the various arms of the immune system. Both innate and
Zanussi S. +4 more
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Immune reconstitution inflammatory syndrome
International Journal of STD & AIDS, 2009The immune reconstitution inflammatory syndrome (IRIS), occurring in chronically HIV-infected patients, is a set of heterogeneous pathological manifestations attributed to an excessive and deregulated immune response to various pathogens and non infectious stimuli shortly after initiation of antiretroviral therapy.
J W T, Elston, H, Thaker
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Immune reconstitution associated hypercalcemia
The American Journal of Emergency Medicine, 2009The emergence of highly active antiretroviral therapy using combinations of reverse transcriptase and protease inhibitors ushered the dawn of a new era in management of human immunodeficiency virus infection. Immune reconstitution inflammatory syndrome is an adverse consequence of the restoration of pathogen-specific immune responses during the early ...
Yu-Tzu, Tsao +3 more
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Immune reconstitution therapy in NMOSD
Multiple Sclerosis and Related Disorders, 2021NMO spectrum disorders [NMOSD] is a relapsing autoimmune disorder with attacks of optic neuritis (ON) and transverse myelitis (TM). A large proportion of NMOSD patients have no or a partial recovery after relapse.The neuro-immunological community now has a number of indicated agents for NMOSD therapy including eculizumab [Soliris®], inebilizumab ...
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Immune reconstitution in HIV infection
Current Opinion in Immunology, 1997Progressive immune deficiency arising during HIV disease reflects the continual degradation and the ultimate deletion of immune specificites defined by the CD4(+) T lymphocyte repertoire. Recent evidence suggests that improvements in the immune function of patients with HIV who receive therapy primarily reflects the expansion of CD4(+) T lymphocyte ...
Emery, S, Lane, HC
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Immune reconstitution strategies in HIV
Current Infectious Disease Reports, 2001Although potent antiretroviral therapy can dramatically decrease HIV replication and improve some aspects of host immunity, incomplete immune reconstitution persists even after several years of fully suppressive therapy. In addition, long-term toxicities of antiretroviral medications and the probability of developing multidrug-resistant virus with long-
Matthew R., Leibowitz +1 more
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