Results 231 to 240 of about 1,305,369 (291)

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Nomogram model for predicting incomplete immune reconstitution in people living with HIV based on clinical characteristics. [PDF]

Front Immunol
Zhang Y, Hu W, Zhang X, Zhang Y, Zhang Z, Jiang Q, Wang S, Nan Y, Song S, Xiong Y.   +9 more
europepmc   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Revisiting Immune-Mediated Mechanisms as Drivers of Cryptococcal Immune Reconstitution Inflammatory Syndrome. [PDF]

Clin Infect Dis
Yoon H, Pirofski LA, Boulware DR.
europepmc   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source

Dynamic immune reconstitution and clinical outcomes in different chimerism statuses of HLA-matched transplantation for severe aplastic anemia. [PDF]

Stem Cells Transl Med
Lin MH, Xu ZL, Chang YJ, Guo HD, Xu LP, Wang Y, Zhang XH, Cheng YF, Zhang YY, Mo XD, Sun YQ, Han TT, Wang JZ, Chen Y, Chen YH, Chen H, Han W, Huang XJ.   +17 more
europepmc   +1 more source

Predicting immune reconstitution after antiretroviral therapy in HIV/AIDS using ensemble machine learning: a real-world study. [PDF]

Front Immunol
Jin J, Li T, Chen J, Ba H, Zhang Y, Li J, Yin J, Liu H, Ma K.   +8 more
europepmc   +1 more source

Case Report: Immune reconstitution-related neurological deterioration in advanced HIV infection with multiple opportunistic infections: a diagnostic challenge. [PDF]

Front Med (Lausanne)
Endara-Mina J, Escudero CJ, Samaniego V, Fuentes K, Tapia W, Intriago C.   +5 more
europepmc   +1 more source

The Impact of Cytomegalovirus Reactivation on Cytomegalovirus-Specific Immune Reconstitution in Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis. [PDF]

Open Forum Infect Dis
Jiang C, Jin L, Wang L, Gu Y, Hu X, Cai G.   +5 more
europepmc   +1 more source

Restorative effect of Rehmanniae radix praeparata on T-cell and NK-cell-mediated immune reconstitution in mice following radiation-induced injury. [PDF]

J Radiat Res
Zheng X, Lan H, Hu Y, Qiu T, Hou H, Tian P.   +5 more
europepmc   +1 more source