Results 51 to 60 of about 27,563 (247)

Immune Reconstitution Inflammatory Syndrome: Opening Pandora’s Box

Case Reports in Infectious Diseases, 2017
One of the purposes of antiretroviral therapy (ART) is to restore the immune system. However, it can sometimes lead to an aberrant inflammatory response and paradoxical clinical worsening known as the immune reconstitution inflammatory syndrome (IRIS ...
Mariana Meireles, Conceição Souto Moura, Margarida França   +2 more
doaj   +1 more source

Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review

Frontiers in Immunology, 2023
Immune reconstitution inflammatory syndrome (IRIS) is characterized by exaggerated and dysregulated inflammatory responses that occur as a result of reconstitution of adaptive or innate immunity.
Xiangyi Song, Ruifeng Duan, Liwei Duan, Lijuan Wei   +3 more
doaj   +1 more source

The immune reconstitution inflammatory syndrome: etiology, pathogenesis, clinical manifestations

, 2019
В умовах поширення захворюваності на ВІЛ-інфекцію у багатьох країнах світу та в Україні, зокрема, пізнього виявлення хворих та збільшення потужності антиретровірусної терапії лікарям усе частіше доводиться зустрічатися із синдромом відновлення імунної ...
Тодоріко, Лілія Дмитрівна, Pentrenko, V.I., Шевченко, О.С., Pohorielova, O.O., Todoriko, L.D., Shevchenko, O.S., Петренко, В.І., Погорєлова, О.О.   +7 more
core   +1 more source

“Chronic Disseminated Aspergillosis,” a Novel Fungal Immune Reconstitution Inflammatory Syndrome

, 2020
International audienceWe report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease.
Mira, Jean-Paul, Olivier Lortholary, Estelle Blanc, Marthe Weinandt, Gregory Jouvion, Blanc, Estelle, Boutboul, David, Romain Guery, Rouquette, Alexandre, Lortholary, Olivier, Julie Bruneau, Jouvion, Gregory, Bruneau, Julie, Lecuit, Marc, Rouzaud, Claire, Claire Rouzaud, David Boutboul, Thierry Jo Molina, Pourbaix, Annabelle, Weinandt, Marthe, Guery, Romain, Jérémy Lourenço, Marc Lecuit, Jean-Paul Mira, Lourenço, Jérémy, Alexandre Rouquette, Annabelle Pourbaix, Molina, Thierry Jo   +27 more
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Histoplasma stomatitis unveiled: Not all opportunistic infections get better after initiation of antiretroviral therapy

Clinical Case Reports, 2021
Immune reconstitution inflammatory syndrome in AIDS patients can lead to an initial worsening of underlying diseases due to body's ability to mount a strong immune response after recovery of CD4 counts.
Saurabh Bansal, Namrata Singhania, Chandra Mouli Nukala, Anil Kumar Singh, Laith Al‐Rabadi   +4 more
doaj   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Immune reconstitution inflammatory syndrome associated with acquired immunodeficiency syndrome-related gastrointestinal limited Kaposi's sarcoma presenting as acute intestinal obstruction: a case report

Journal of Medical Case Reports, 2011
Introduction Immune reconstitution inflammatory syndrome during anti-retroviral treatment of acquired immunodeficiency syndrome (AIDS) -associated gastrointestinal Kaposi's sarcoma has rarely been reported.
Pathak Hari, Shrivastav Ankit, Pal Jyotirmoy, Sarkar Dipendra   +3 more
doaj   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Tuberculosis IRIS: a mediastinal problem [v2; ref status: indexed, http://f1000r.es/1e5]

F1000Research, 2013
We present a case of a 39 year old male patient with Acquired Immune Deficiency Syndrome (AIDS) who developed Mycobacterium tuberculosis related Immune Reconstitution Inflammatory Syndrome (IRIS) after initiation of Highly Active Antiretroviral Therapy ...
Leonardo Valentin, Andrew DiNardo, Elizabeth Chiao, Laila Woc-Colburn, Arun Nachiappan   +4 more
doaj   +1 more source