Results 121 to 130 of about 8,136,838 (310)

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

Frontiers in Immunology
BackgroundPD-L1 expression is widely used as a predictive biomarker for anti-PD-1 therapies in non-small cell lung cancer (NSCLC). However, its prognostic value remains controversial.
Morgane Peroz, Nicolas Roussot, Nicolas Roussot, Alis Ilie, David Rageot, Valentin Derangere, Valentin Derangere, Caroline Truntzer, Caroline Truntzer, François Ghiringhelli, François Ghiringhelli, François Ghiringhelli   +11 more
doaj   +1 more source

Artificial Immune Systems: A Novel Approach to Pattern Recognition [PDF]

, 2002
This chapter introduces a new computational intelligence paradigm to perform pattern recognition, named Artificial Immune Systems (AIS). AIS take inspiration from the immune system in order to build novel computational tools to solve problems in a vast ...
Timmis, Jon, de Castro, Leandro N.
core  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination [PDF]

, 2010
Includes bibliographical references (leaves 102-114).Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem.
Dube, Frederick
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Metabolites beyond metabolism: Exploring their atypical roles in protein modification and signaling transduction

Chinese Medical Journal
. This comprehensive review explores the atypical metabolic roles of metabolites, extending beyond their conventional functions in energy production and biosynthesis.
Wenjuan Yang, Jingxia Wu, Guoliang Cui, Jing Ni   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease

Nature Communications
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for many malignant and nonmalignant hematological diseases. Our recent research demonstrated that early-day stem cell infusions significantly reduce the incidence ...
Yue Wu, Yiwen Hou, Dongyao Wang, Liang Wang, Kaidi Song, Guangyu Sun, Aijie Huang, Meijuan Tu, Lu Huang, Jialin Zhou, Weiwei Wu, Baolin Tang, Cheng Zhan, Xiaoyu Zhu   +13 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source