Results 151 to 160 of about 2,258,994 (317)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Author Correction: NRF1-mediated innate immune response drives inflammaging. [PDF]

Nat Commun
Lei H, Zhao T, Zhang J, Long Y, Chen Y, Zhu Y, Meng Y, Tang Y, Liu X, Sun J, Li Z, Su J, Gong F, Chen G, Sun B, Chen Y, Chen Q, Li Y, Zhu Y.   +18 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Addendum: Neural anticipation of virtual infection triggers an immune response. [PDF]

Nat Neurosci
Trabanelli S, Akselrod M, Fellrath J, Vanoni G, Bertoni T, Serino S, Papadopoulou G, Born M, Girondini M, Ercolano G, Ellena G, Cornu A, Mastria G, Gallart-Ayala H, Ivanisevic J, Grivaz P, Paladino MP, Jandus C, Serino A.   +18 more
europepmc   +1 more source

Sheep Red Blood Cell Immune Assay

, 2013
Protocol for measuring immune response to injection of sheep red blood cells ...
Devin Zysling
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Genome instability and crosstalk with the immune response. [PDF]

Genome Med
Chabanon RM, Danlos FX, Ouali K, Postel-Vinay S.   +3 more
europepmc   +1 more source

Systemic Immune-Inflammation Index and Systemic Inflammation Response Index Predict the Response to Radioiodine Therapy for Differentiated Thyroid Cancer

Yan Wang,1,2 Junshun Chang,1 Ben Hu,3 Suyun Yang1 1Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, People’s Republic of China; 2Academy of Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi,
Wang Y, Chang J, Hu B, Yang S
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Observed Immune Response Following Histotripsy in Metastatic Hepatocellular Carcinoma. [PDF]

Case Rep Oncol Med
Staley C, Dakkak T, Robinson SS, Royall NA.   +3 more
europepmc   +1 more source