Results 271 to 280 of about 12,342,164 (400)

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source

Corrigendum to “Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis” [Heliyon Volume 6, Issue 12, December 2020, Article e05635]

Heliyon
José Avendaño-Ortiz, Roberto Lozano-Rodríguez, Alejandro Martín-Quirós, Charbel Maroun-Eid, Verónica Terrón, Jaime Valentín, Karla Montalbán-Hernández, Fátima Ruiz de la Bastida, Miguel A. García-Garrido, Carolina Cubillos-Zapata, Álvaro del Balzo-Castillo, Luis A. Aguirre, Eduardo López-Collazo   +12 more
doaj   +1 more source

Decoding leprosy: immune response, clinical manifestations and emerging diagnostic approaches. [PDF]

Trans R Soc Trop Med Hyg
Serrano-Coll H, Restrepo-Rivera L, Cuadros-Urrego Y, Cardona-Castro N.   +3 more
europepmc   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Editorial: Genes, cells, and macroenvironments: regulating the immune response in extreme conditions. [PDF]

Front Immunol
Pennesi G.
europepmc   +1 more source

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor.

Immunity, 2018
Cristina Gutiérrez-Vázquez, F. Quintana   +1 more
semanticscholar   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source

Vitamin D3 encapsulated in polymeric nanoparticles to dampen the pro-inflammatory immune response. [PDF]

J Transl Autoimmun
Minnee J, Cuenca-Escalona J, Bödder J, Flórez-Grau G, de Jong EC, de Vries IJM.   +5 more
europepmc   +1 more source

Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi‐domain function and disability.
Chen Hu, Jiyeon Son, Lindsay McAlpine, Elizabeth L. S. Walker, Megan Dahl, Emily Song, Sugeidy Ferreira Brito, Katelyn Kavak, Kaho Onomichi, Amit Bar‐Or, Christopher Perrone, Claire S. Riley, Bianca Weinstock‐Guttman, Philip L. De Jager, Erin E. Longbrake, Zongqi Xia   +15 more
wiley   +1 more source

Understanding the tumor immune microenvironment (TIME) for effective therapy

Nature Network Boston, 2018
M. Binnewies, Edward W. Roberts, K. Kersten, Vincent Chan, Douglas Fearon, M. Merad, L. Coussens, D. Gabrilovich, S. Ostrand-Rosenberg, S. Ostrand-Rosenberg, C. Hedrick, R. Vonderheide, M. Pittet, R. Jain, W. Zou, T. Howcroft, E. Woodhouse, R. Weinberg, M. Krummel   +18 more
semanticscholar   +1 more source