Results 161 to 170 of about 26,342,104 (415)

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

open access: yesMolecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang   +10 more
wiley   +1 more source

An aged immune system drives senescence and ageing of solid organs

open access: yesNature, 2021
Matthew J. Yousefzadeh   +32 more
semanticscholar   +1 more source

TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells.

open access: yesCancer Research, 2017
Recent clinical successes of cancer immunotherapy necessitate the investigation of the interaction between malignant cells and the host immune system. However, elucidation of complex tumor-immune interactions presents major computational and experimental
Taiwen Li   +7 more
semanticscholar   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Infection-acquired versus vaccine-acquired immunity in an SIRWS model [PDF]

open access: yesarXiv, 2017
Despite high vaccine coverage, pertussis has re-emerged as a public health concern in many countries. One hypothesis posed for re-emergence is the waning of immunity. In some disease systems, the process of waning immunity can be non-linear, involving a complex relationship between the duration of immunity and subsequent boosting of immunity through ...
arxiv  

COVID-19 and the human innate immune system

open access: yesCell, 2021
J. Schultze, A. Aschenbrenner
semanticscholar   +1 more source

Structure and function of the immune system in the spleen

open access: yesScience immunology, 2019
The spleen is a multitasking secondary lymphoid organ with specialized cells for initiating immunity to blood-borne targets. The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide range of immunologic functions ...
S. Lewis, Adam Williams, S. Eisenbarth
semanticscholar   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity

open access: yesFrontiers in Immunology, 2019
Granzymes (Gzm) are serine proteases, contained into the secretory granules of cytotoxic cells, responsible for the cell-mediated cytotoxicity (CMC) against tumor cells and intracellular pathogens such as virus and bacteria.
Elena Chaves-Pozo   +8 more
doaj   +1 more source

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