Results 281 to 290 of about 24,697,135 (341)

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

open access: yesArthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla   +13 more
wiley   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

open access: yesAdvanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer   +8 more
wiley   +1 more source
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The immune system

Anaesthesia & Intensive Care Medicine, 2009
The immune system provides the body with both non-specific and specific defence against pathogens. It can recognize foreign from self. The immune system is composed of lines of defence and can mount responses by cellular and humoral mechanisms. It also has memory, allowing a quicker and heightened response on subsequent exposure.
Cota, Allwyn M., Midwinter, Mark J.
openaire   +3 more sources

The Immune System

American Journal of Health-System Pharmacy, 1986
The components and functions of the immune system are described, and the clinical applications of agents that affect the immune system are discussed. Through both nonspecific and specific responses, the immune system recognizes and destroys or eliminates harmful foreign substances with which a host comes into contact.
Joshua J. Thompson, Parr, JA Tami
openaire   +3 more sources

Immune System

2022
This chapter discusses the components and purpose of the immune system. The immune system is designed to recognize and destroy anything dangerous to the body, which includes pathogens and tumour cells. In the absence of a functional immune system, people quickly become sick and die if they do not have the intervention of modern medicine.
Jon Scott   +9 more
openaire   +1 more source

TISIDB: an integrated repository portal for tumor-immune system interactions

Bioinform., 2019
SUMMARY The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor-immune interactions, we have designed a user-friendly web portal TISIDB ...
Beibei Ru   +11 more
semanticscholar   +1 more source

Sphingolipids and the immune system

Pharmacological Research, 2003
The importance of sphingolipids, not only as components of plasma membranes but also as key players in different physiological and pathophysiological cellular events, is now emerging. This review gathers together what the authors feel are the most relevant data, present in the literature, regarding the roles and the effects of sphingolipids, such as ...
CINQUE, BENEDETTA   +5 more
openaire   +6 more sources

Systemic immunity

Current Opinion in Plant Biology, 2006
Systemic acquired resistance (SAR) provides enhanced, long-lasting systemic immunity to secondary infection by a range of biotrophic, hemibiotrophic and necrotrophic pathogens that have diverse modes of infection. Considerable effort has focussed on the conserved central positive regulator of SAR, NON-EXPRESSOR OF PATHOGENESIS-RELATED1 (NPR1), and its ...
Murray, Grant, Chris, Lamb
openaire   +2 more sources

The immune system

Anaesthesia & Intensive Care Medicine, 2018
Abstract This article intends to provide an up-to-date overview of the relevant physiology required to pass the FRCA. The immune system is our defence against pathogens. This includes the recognition of non-self organisms, and protection through a variety of non-specific and highly specific mechanisms.
Malcolm Shepherd, Malcolm Howell
openaire   +2 more sources

Immune System

2013
Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased ...
Ruehl-Fehlert, C.   +3 more
openaire   +5 more sources

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