Results 151 to 160 of about 3,749,228 (399)

Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs [PDF]

, 2014
The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions.
Manjili, Masoud H.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., Balbao, J., Cabrera, O., Cuello, M., del Campo, J., Ferro, Valerie A., Gonzales, E., Romeu, B., Zayas, C.   +8 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality [PDF]

, 2020
Lucinda Smart, Neil Fawkes, Paul Goggin, Graham Pennick, K. D. Rainsford, Bruce Charlesworth, Neil Shah   +6 more
openalex   +1 more source

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]

, 2020
Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing, Fang, Meijuan, Greer, Justin, Hu, Jiaqi, Magnuson, Jason T, Qiu, Wenhui, Schlenk, Daniel, Yang, Ming, Zheng, Chunmiao   +8 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development

Cell Reports
Summary: Eos, a member of the Ikaros family of transcription factors, is expressed by T regulatory cells (Tregs) and has been postulated to play a role in Treg suppression and maintenance of Treg stability.
Xuan Xie, Angela M. Thornton, Shalini Tanwar, Patricia Korty, Alexandria C. Wells, Elisha Segrist, Ana Teijeiro, Claudia A. Rivera, Danping Wei, Xi Chen, Jinfang Zhu, Asya Khleborodova, Tom Hill, Tovah E. Markowitz, Margery Smelkinson, Juraj Kabat, Tibor Veres, Owen M. Schwartz, Francisco Otaizo-Carrasquero, Paul Gardina, Amirhossein Shamsaddini, Craig Martens, Kyoungin Cho, Cheng-Chao Lin, Jaspal S. Khillan, Yelena Levin, Ying Wu, Ethan M. Shevach   +27 more
doaj   +1 more source

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function [PDF]

, 2016
Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, Mathew Blurton‐Jones   +12 more
openalex   +1 more source

Modeling of immune life history and body growth: the role of antigen burden [PDF]

In this paper, a recently developed mathematical model of age related changes in population of peripheral T cells (Romanyukha, Yashin, 2003) is used to describe ontogenetic changes of the immune system.
Alexei A. Romanyukha, Anatoli I. Yashin, Sergey G. Rudnev   +2 more
core