Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
“Listen to Your Immune System When It’s Calling for You”: Monitoring Autoimmune Diseases Using the iShU App [PDF]
, 2022 Cláudia Pedro Ortet, Liliana Vale Costa
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Immune System as a Therapeutic Target for Alzheimer’s Disease [PDF]
, 2022 Tarek Zieneldien +3 more
openalex +1 more source
Tipping the balance: targeting the thymus for production of immune cells protective against Auto-Immune Disease [PDF]
, 2015 The thymus is the unique site of production of T-cells, an essential arm of the adaptive immune system which is targeted by vaccinations as a defense against infectious diseases.
McCarthy, Nick
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cognitively Healthy Centenarians are genetically protected against Alzheimer’s disease specifically in immune and endo-lysosomal systems [PDF]
, 2023 Niccoló Tesi +8 more
openalex +1 more source
What Immunological Defects Predispose to Non-tuberculosis Mycobacterial Infections? [PDF]
, 2017 Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil. NTM cause a variety of diseases in humans that mainly affect the lung.
Adcock, IM +7 more
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Risk factors for severe COVID-19 outcomes: a study of immune-mediated inflammatory diseases, immunomodulatory medications, and comorbidities in a large US healthcare system [PDF]
, 2023 Qi Wei +10 more
openalex +1 more source