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The role of the immune system in Alzheimer’s disease
Ageing Research Reviews, 2021Alzheimer's disease (AD) is the most common neurodegenerative disorder where the accumulation of amyloid plaques and the formation of tau tangles are the prominent pathological hallmarks. Increasing preclinical and clinical studies have revealed that different components of the immune system may act as important contributors to AD etiology and ...
Kai-Min Wu +5 more
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Atopic disease, immune system, and the environment
Allergy and Asthma Proceedings, 2007Raised prevalence of allergic respiratory diseases observed in the last 20 years seems to be associated with changes of environment and lifestyle, which favor a delayed acquisition of Th1 function in childhood. The purpose of this study is to review recent knowledge concerning the developing human immune system and its interaction with external ...
LEONARDI S +3 more
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MicroRNAs, the immune system and rheumatic disease
Nature Clinical Practice Rheumatology, 2008MicroRNAs (miRNAs) are short noncoding RNA molecules that modulate the expression of multiple target genes at the post-transcriptional level and are implicated in a wide array of cellular and developmental processes. In hematopoietic cells, miRNA levels are dynamically regulated during lineage differentiation and also during the course of the immune ...
Esmerina, Tili +3 more
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The maternal immune system in health and disease
Current Opinion in Obstetrics and Gynaecology, 1998Recent studies have clarified some characteristics of trophoblast and immune cells in the decidua and peripheral blood during pregnancy and the roles they play in the maternal immune system, and have added further evidence to the theory that maternal T helper cell type 1/2 cytokine balance shifts towards T helper cell type 2 dominance during pregnancy.
Y, Iwatani, M, Watanabe
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Parkinson's Disease: A Role for the Immune System
Current Molecular Pharmacology, 2013Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to
Dwight C, German +2 more
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Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated Diseases
Current Pharmaceutical Design, 2008The immune system has evolved sophisticated mechanisms controlling the development of responses to dangerous antigens while avoiding unnecessary attacks to innocuous, commensal or self antigens. The risk of autoimmunity is continuously checked and balanced against the risk of succumbing to exogenous infectious agents.
GIOVANNETTI A +7 more
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The diversity of retroviral diseases of the immune system
Immunology & Cell Biology, 1992SummaryRetroviruses have been implicated as causative agents for a range of diseases including neoplasia, autoimmunity and immunosuppression. No two retroviruses carry the same complement of genes and for this reason it is not surprising that they induce a variety of different disease states. One common element in retroviral evolution has been the need
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Activation of the Innate Immune System in Atherosclerotic Disease
Current Pharmaceutical Design, 2007Innate immunity is the first line of defence against invading micro-organisms. The family of Toll-like receptors (TLRs) recognizes pathogen-associated molecular patterns (PAMPs) that are carried by the invading micro-organisms. Infectious pathogens have been implicated to play an important role in atherosclerosis.
Oude Nijhuis, M.M. +4 more
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Endocannabinoids and the Immune System in Health and Disease
2015Endocannabinoids are bioactive lipids that have the potential to signal through cannabinoid receptors to modulate the functional activities of a variety of immune cells. Their activation of these seven-transmembranal, G protein-coupled receptors sets in motion a series of signal transductional events that converge at the transcriptional level to ...
Guy A, Cabral +2 more
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The immune system in Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized as a progressive and chronic disorder that leads to the destruction of cholinergic neurons. AD was studied by Alois Alzheimer, a psychiatrist and neuroanatomist, who reported the pathology as amyloidal fibrillar deposits located in the walls of blood vessels, associated with a ...Juliane Maria Alves Nogueira +5 more
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