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Atopic disease, immune system, and the environment
Allergy and Asthma Proceedings, 2007Raised prevalence of allergic respiratory diseases observed in the last 20 years seems to be associated with changes of environment and lifestyle, which favor a delayed acquisition of Th1 function in childhood. The purpose of this study is to review recent knowledge concerning the developing human immune system and its interaction with external ...
LEONARDI S +3 more
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Ascorbic acid: its role in immune system and chronic inflammation diseases.
Mini-Reviews in Medical Chemistry, 2014Ascorbic acid (AA), also known as vitamin C, was initially identified as the factor preventing the scurvy disease, and became very popular for its antioxidant properties.
A. Sorice +5 more
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MicroRNAs, the immune system and rheumatic disease
Nature Clinical Practice Rheumatology, 2008MicroRNAs (miRNAs) are short noncoding RNA molecules that modulate the expression of multiple target genes at the post-transcriptional level and are implicated in a wide array of cellular and developmental processes. In hematopoietic cells, miRNA levels are dynamically regulated during lineage differentiation and also during the course of the immune ...
Stefan Costinean +4 more
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The maternal immune system in health and disease
Current Opinion in Obstetrics and Gynaecology, 1998Recent studies have clarified some characteristics of trophoblast and immune cells in the decidua and peripheral blood during pregnancy and the roles they play in the maternal immune system, and have added further evidence to the theory that maternal T helper cell type 1/2 cytokine balance shifts towards T helper cell type 2 dominance during pregnancy.
Yoshinori Iwatani, Mikio Watanabe
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Parkinson's Disease: A Role for the Immune System
Current Molecular Pharmacology, 2013Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to
Patricia K. Sonsalla +2 more
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Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated Diseases
Current Pharmaceutical Design, 2008The immune system has evolved sophisticated mechanisms controlling the development of responses to dangerous antigens while avoiding unnecessary attacks to innocuous, commensal or self antigens. The risk of autoimmunity is continuously checked and balanced against the risk of succumbing to exogenous infectious agents.
GIOVANNETTI A +7 more
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Alcoholic Liver Disease and the Immune System
JAMA: The Journal of the American Medical Association, 1975The immune system and various hepatic diseases appear to be closely related; indeed, immunologic abnormalities are described in various hepatic disorders. For instance, primary biliary cirrhosis is associated with the presence of antimitochondrial antibodies and with a decreased response of blood lymphocytes to phytohemagglutinin, suggesting a defect ...
Wybran, Joseph +2 more
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The diversity of retroviral diseases of the immune system
Immunology & Cell Biology, 1992SummaryRetroviruses have been implicated as causative agents for a range of diseases including neoplasia, autoimmunity and immunosuppression. No two retroviruses carry the same complement of genes and for this reason it is not surprising that they induce a variety of different disease states. One common element in retroviral evolution has been the need
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Endocannabinoids and the Immune System in Health and Disease
2015Endocannabinoids are bioactive lipids that have the potential to signal through cannabinoid receptors to modulate the functional activities of a variety of immune cells. Their activation of these seven-transmembranal, G protein-coupled receptors sets in motion a series of signal transductional events that converge at the transcriptional level to ...
Gabriela A. Ferreira +2 more
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