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Parkinson's Disease: A Role for the Immune System
Current Molecular Pharmacology, 2013Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to
Patricia K. Sonsalla +2 more
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Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated Diseases
Current Pharmaceutical Design, 2008The immune system has evolved sophisticated mechanisms controlling the development of responses to dangerous antigens while avoiding unnecessary attacks to innocuous, commensal or self antigens. The risk of autoimmunity is continuously checked and balanced against the risk of succumbing to exogenous infectious agents.
GIOVANNETTI A +7 more
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Alcoholic Liver Disease and the Immune System
JAMA: The Journal of the American Medical Association, 1975The immune system and various hepatic diseases appear to be closely related; indeed, immunologic abnormalities are described in various hepatic disorders. For instance, primary biliary cirrhosis is associated with the presence of antimitochondrial antibodies and with a decreased response of blood lymphocytes to phytohemagglutinin, suggesting a defect ...
Wybran, Joseph +2 more
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The diversity of retroviral diseases of the immune system
Immunology & Cell Biology, 1992SummaryRetroviruses have been implicated as causative agents for a range of diseases including neoplasia, autoimmunity and immunosuppression. No two retroviruses carry the same complement of genes and for this reason it is not surprising that they induce a variety of different disease states. One common element in retroviral evolution has been the need
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Endocannabinoids and the Immune System in Health and Disease
2015Endocannabinoids are bioactive lipids that have the potential to signal through cannabinoid receptors to modulate the functional activities of a variety of immune cells. Their activation of these seven-transmembranal, G protein-coupled receptors sets in motion a series of signal transductional events that converge at the transcriptional level to ...
Gabriela A. Ferreira +2 more
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Activation of the Innate Immune System in Atherosclerotic Disease
Current Pharmaceutical Design, 2007Innate immunity is the first line of defence against invading micro-organisms. The family of Toll-like receptors (TLRs) recognizes pathogen-associated molecular patterns (PAMPs) that are carried by the invading micro-organisms. Infectious pathogens have been implicated to play an important role in atherosclerosis.
Oude Nijhuis, M.M. +4 more
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The Intestinal Immune System and Its Relation to Disease
Digestive Diseases, 1993The essential protective structure against the heavy enteric antigenic burden, the gut mucosa, prevents penetration of noxious agents, but allows a minimal exchange of large molecules and particles between the gut lumen and the 'milieu intérieur' of the body.
Borisch Chappuis +4 more
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3 The humoral immune system in coeliac disease
Baillière's Clinical Gastroenterology, 1995IgA is transported into intestinal secretions to perform exclusion of luminal antigens. The prerequisites are antigen sampling by the Peyer's patch M cells, antigen processing by antigen-presenting cells, and presentation of antigenic peptides by HLA class II molecules to immunocompetent T-cells.
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Neuromodulation by the immune system: a focus on cytokines
Nature reviews. Immunology, 2021A. F. Salvador, K. A. de Lima, J. Kipnis
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