Results 71 to 80 of about 929,863 (265)

Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy

Frontiers in Immunology
Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain critical problems in resistant cases. Melanoma employs a multitude of mechanisms to
Carl A Shirley, G. Chhabra, Deeba Amiri, Hao Chang, Nihal Ahmad   +4 more
semanticscholar   +1 more source

Investigational Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Event Prediction and Diagnosis.

Clinical Chemistry, 2020
BACKGROUND Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of multiple cancers. However, these promising therapies may also cause immune-related adverse events (irAEs) in a substantial proportion of patients.
Mitchell S. von Itzstein, Shaheen Khan, D. Gerber   +2 more
semanticscholar   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Modulation of immune functions by oestrogens. Part II

Menopause Review, 2010
One of the most important functions of oestrogens is modulation of the immune system. By interactionswith specific oestrogen receptors ERα and ERβ these sex steroid hormones are capable of regulating manyaspects of both natural and adaptive immunity ...
Jacek R. Wilczyński
doaj  

A behavioural immune system perspective on disgust and social prejudice

Nature Reviews Psychology, 2023
F. van Leeuwen, Bastian Jaeger, J. Tybur
semanticscholar   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Distributed delays in a hybrid model of tumor-immune system interplay.

Mathematical biosciences and engineering : MBE, 2012
A tumor is kinetically characterized by the presence of multiple spatio-temporal scales in which its cells interplay with, for instance, endothelial cells or Immune system effectors, exchanging various chemical signals.
G. Caravagna, Alex Graudenzi, A. d’Onofrio   +2 more
semanticscholar   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A key to the backdoor into the castle: The clinical ramifications of immunoediting driven by antigenic competition

Human Vaccines & Immunotherapeutics, 2017
Over the last decade the field of cancer biology has gained considerable data on genomic heterogeneity. This situation creates challenges and possibly opportunities for cancer treatment.
M. G. Hanna, Jason D. Howard
doaj   +1 more source

The IL-1β phenomena in neuroinflammatory diseases

Journal of neural transmission, 2017
It is becoming increasingly clear that neuroinflammation has a causal role in the pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic strategies targeting the regulation or availability of inflammatory mediators can ...
Andrew S. Mendiola, A. Cardona
semanticscholar   +1 more source