Results 191 to 200 of about 1,171,277 (292)

Emerging targeted therapies for primary immune thrombocytopenia: novel agents, combination strategies, and future directions. [PDF]

Front Pharmacol
Wang Z, Yang W, Xu N, Ma L, Wang A, Liu B.   +5 more
europepmc   +1 more source

Efficacy and safety of high doses of eltrombopag for treating adult immune thrombocytopenia: Results from a multicentre retrospective cohort study

British Journal of Haematology, EarlyView.
Salomé Dahan, Stéphanie Guillet, Olivier Fain, Delphine Gobert, Stéphane Cheze, Florent Broca, Bertrand Godeau, Marc Michel   +7 more
wiley   +1 more source

Severe immune thrombocytopenia induced by vancomycin in a critically ill patient: a case report and literature review. [PDF]

Thromb J
Khoshnam Rad N, Ghasemi F, Firouzbakhsh S, Rashidinejad B.   +3 more
europepmc   +1 more source

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

British Journal of Haematology, EarlyView.
Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections between 2023 and 2025, including symptoms, laboratory parameters ...
Matthias Bleeke, Arne Simon, Beate Winkler, Sabine Heine, Anna Eichinger, Ulrich von Both, Meinolf Siepermann, Sonya El Amouri, Arndt Borkhardt, Yvonne Pritschow, Wolfgang Novak, Michael Dworzak, Sarah Goretzki, Clara Held, Karin Beutel, Franziska Gams, Henriette Rudolph, Leila Koscher, Piet E. Beusker, Eckard Hamelmann, Stefan Weichert, Svenja Häuser, Maximilian Mauritz, Malik Aydin, Verena Wiegering, Regine Grosse, Rainer Misgeld, Martina Stiefel, Nicole Töpfner, Uta Falke, Lara Imhof, Laura Tagliaferri, Daniel Ebrahimi‐Fakhari, Andreas Groll, Marion Appel, Nora Naumann‐Bartsch, Michaela Nathrath, Olaf Beck, Solvej Heidtmann, Philipp Tischer, Ulf Schulze‐Sturm, Urs Mücke, Holger Cario   +42 more
wiley   +1 more source

Neutrophil-derived S100A8/A9 impairs megakaryocyte maturation in immune thrombocytopenia. [PDF]

Nat Commun
Qi J, Zhou M, Yin J, Song X, Zhang Y, Han H, Li X, Zhang Z, Tang Y, Yang F, Wu D, Li Z, Han Y.   +12 more
europepmc   +1 more source

A phase IIa study of the anti‐PD‐L1 antibody avelumab in relapsed/refractory PTCL: The AVAIL‐T trial

British Journal of Haematology, EarlyView.
The AVAIL‐T study, the first evaluation of programmed death ligand 1 (PD‐L1) blockade in relapsed/refractory peripheral T‐cell lymphomas (PTCL), demonstrated limited single agent activity with durable responses seen in a minority. Circulating tumour DNA revealed distinct mutational dynamics and mass cytometry identified perturbed T‐cell subsets ...
Matthew J. Ahearne, Matthew A. Timmins, Charlotte Gaskell, Aimee Jackson, Clare Morland, Sonia Fox, Louise Hopkins, Nadia Nawaz, Susann Lehmann, Marc Wadsley, Caroline Cowley, Jacqueline Shaw, Naeem Khan, Nagesh Kalakonda, Christopher Trethewey, Ram Malladi, Paul Fields, Dima El Sharkawi, Michael Quinn, Nimish Shah, Andrew Davies, Kim Linton, Pam McKay, Rod Johnson, Simon D. Wagner, David Lewis, Graham P. Collins, Christopher P. Fox, Kate Cwynarski   +28 more
wiley   +1 more source

Avatrombopag in heavily pretreated chronic immune thrombocytopenia: a single center experience from Oman. [PDF]

Front Med (Lausanne)
Al-Sharji N, Salman B, Al-Zadjali S, Al-Huneini M.   +3 more
europepmc   +1 more source

Unusual yet isolated oral manifestations of persistent thrombocytopenia A rare case report

s with platelet-mediated disorders often present clinical manifestations of bruising and bleeding. Although these changes are detected most frequently on the skin, the oral cavity also may exhibit signs of bleeding.
Amit Byatnal, Neha Mahajan, Shrinivas Koppal, A Ravikiran, Thriveni R, Parvathi Devi M K
core  

Relevance of anti‐thyroperoxidase antibodies in immune thrombocytopenia in adults: A single‐centre cohort study

British Journal of Haematology, EarlyView.
Nicolas Duhamel, Marie Ottavi, Sarah Lechtman, Nihal Martis, Charlotte Hinault‐Boyer, Julie Merindol, Pierre‐Yves Jeandel, Michael Levraut   +7 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source