Results 181 to 190 of about 129,754 (292)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

A practical approach to immune thrombocytopenia in pregnancy. [PDF]

Hematology Am Soc Hematol Educ Program
Matusiak K, Malinowski AK, Arnold DM.
europepmc   +1 more source

Fostamatinib treatment for patients with antiphospholipid syndrome and low platelet count: A case series

British Journal of Haematology, EarlyView.
Ekaterina Balaian, Rosa Sonja Alesci, Sandra Marten, Julia‐Annabell Georgi, Christiane Naue, Martin Bornhäuser, Karolin Trautmann‐Grill   +6 more
wiley   +1 more source

Novel use of telitacicept in primary immune thrombocytopenia: a case report. [PDF]

BMC Pediatr
Wang Y, Wang J, Hu B, Zhou Y, Rao Y, Lu M, Xu X.   +6 more
europepmc   +1 more source

Short‐ and long‐term outcome of neonates with thrombocytopenia from maternal immune thrombocytopenia

British Journal of Haematology, EarlyView.
Boris Sorin, Billal Azzouguen, Valentine Loustau, Emmanuelle Boutin, Helene Henique, Julie Graveleau, Odile Souchaud‐Debouverie, Laurent Pascal, Laurent Gilardin, Nathalie Costedoat‐Chalumeau, Quitterie Reynaud, Brigitte Pan‐Petesch, Stéphane Cheze, Louis Terriou, Thibault Comont, Gaetan Sauvetre, Bruno Royer, Matthieu Mahévas, Marc Michel, Florence Canoui‐Poitrine, Bertrand Godeau, Stéphanie Guillet   +21 more
wiley   +1 more source

Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)

Diabetic Medicine, EarlyView.
Abstract Introduction In 2025, the Medicines and Healthcare products Regulatory Agency (MHRA) approved the use of teplizumab (a monoclonal anti‐CD3 antibody) to delay progression from Stage 2 to Stage 3 Type 1 diabetes in the UK. Methods To address the need for clear guidance on managing patients eligible for teplizumab therapy, the British Society of ...
Renuka P. Dias, M. Loredana Marcovecchio, Ruben H. Willemsen, Fiona Campbell, Ahmad Ashour, Philip Newland‐Jones, Jennifer Cooper, Parth Narendran, Neil P. Wright   +8 more
wiley   +1 more source

Safety and efficacy of daratumumab in immune thrombocytopenia. [PDF]

Blood Adv
Tsykunova G, Holme PA, Tran HTT, Frederiksen H, Tjønnfjord E, Munthe LA, Drivet E, Kared H, Sørvoll IH, Ahlen MT, Mahévas M, Michel M, Bussel J, Kuter DJ, Anderson Tvedt TH, Ghanima W.   +15 more
europepmc   +1 more source

Clinical use of immunosuppressants [PDF]

, 2005
Fung, JJ, Schonder, KS, Starzl, TE, Weber, RJ   +3 more
core  

Lack of association between vaccine‐induced immune thrombocytopenia and thrombosis and HLA loci in a large cohort

British Journal of Haematology, EarlyView.
Linda Schönborn, Ana Tzvetkova, Thomas Thiele, Uwe Völker, Sabine Ameling, Sören Franzenburg, Lars Kaderali, Andreas Greinacher   +7 more
wiley   +1 more source

Targeting Ikaros and Aiolos: Next‐Generation Cereblon E3 Ligase Modulators in MM

European Journal of Haematology, EarlyView.
The graphical abstract illustrates the mechanism of action of cereblon E3 ligase modulators (CELMoDs) in multiple myeloma, highlighting cereblon‐mediated degradation of IKZF1 and IKZF3. Compared with classical immunomodulatory drugs (IMiDs), CELMoDs induce deeper IKZF1/3 depletion, leading to more pronounced suppression of the IRF4–MYC survival axis ...
Maria Eugenia Alvaro, Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source