Results 131 to 140 of about 2,852,359 (355)

Dectin-1 Activation on Macrophages by Galectin-9 Promotes Pancreatic Carcinoma and Peritumoral Immune-Tolerance

Nature Network Boston, 2017
The progression of pancreatic oncogenesis requires immune-suppressive inflammation in cooperation with oncogenic mutations. However, the drivers of intratumoral immune tolerance are uncertain. Dectin 1 is an innate immune receptor crucial for anti-fungal
Donnele Daley, Vishnu R Mani, Navyatha Mohan, Neha Akkad, A. Ochi, Daniel W. Heindel, Ki Buom Lee, Constantinos P Zambirinis, Gautam S D Balasubramania Pandian, Shivraj Savadkar, Alejandro Torres‐Hernandez, Shruti D Nayak, Ding Wang, Mautin Hundeyin, B. Diskin, Berk Aykut, G. Werba, Rocky M. Barilla, R. Rodriguez, Steven Y. Chang, Lawrence B. Gardner, L. Mahal, B. Ueberheide, G. Miller   +23 more
semanticscholar   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Regulatory B cells in pregnancy: lessons from autoimmunity, graft tolerance, and cancer [PDF]

, 2017
The success of pregnancy is contingent on the maternal immune system recognizing and accommodating a growing semi-allogeneic fetus. Specialized subsets of lymphocytes capable of negative regulation are fundamental in this process, and include the ...
Alijotas-Reig, Bermejo, Bigot, Blair, Blair, Blois, Bodhankar, Bodhankar, Bodhankar, Bodhankar, Carter, Carter, Chaouat, Chen, Chesneau, de Man, de Waal Malefyt, Deng, Di Caro, Ding, Duddy, El Fassi, Enninga, Evans, Faas, Fillatreau, Fiorentino, Flores-Borja, Ganti, Gao, Garay, Goetz, Grivennikov, Harrell, Heinemann, Hirotani, Huarte, Inoue, Iwata, Jara, Jensen, Jorgensen, Kallikourdis, Katz, Khan, Knippenberg, Korniotis, Kyurkchiev, Lampropoulou, Lee, Leibler, Lenert, Lima, Lin, Lindner, Lopez-Medina, Lundy, Mann, Maseda, Matsushita, Matsushita, Matsushita, Mauri, Mauri, Menon, Minagawa, Mizoguchi, Mizoguchi, Montandon, Moreau, Murphy, Muzzio, Muzzio, Neta, Newell, Newell, Niimi, Nova-Lamperti, Nova-Lamperti, Olkhanud, Ostensen, O’Garra, Parham, Parker, Pestka, Phiel, Polanczyk, Polanczyk, Polanczyk, Ray, Ray, Robertson, Robertson, Rolle, Rolle, Rosser, Roussey-Kesler, Ruddell, Ruocco, Rutella, Sarvaria, Schumacher, Segerer, Shabir, Shalapour, Shao, Shen, Shimabukuro-Vornhagen, Silva, Subramanian, Sun, Szekeres-Bartho, Tai, Tan, Tang, Terrone, Thompson, Wang, Watanabe, Wei, White, Wolf, Yan, Yanaba, Yanaba, Yang, Yates, Yeung, Zenclussen, Zhang, Zhang, Zhang, Zhao, Zhou, Zhou   +134 more
core   +1 more source

Sea squirts and immune tolerance [PDF]

Disease Models & Mechanisms, 2009
Transplantation specificity and protective immunity occur in both adaptive and innate branches of the vertebrate immune system. Understanding the mechanisms that underlie specificity and self-tolerance of immune function has major significance, from preventing a rejection reaction after transplantation to dissecting the causes of autoimmune disease ...
openaire   +3 more sources

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

HLA-DRB1 allele distribution in Chilean population: insights into rheumatoid arthritis susceptibility and protection

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is an autoimmune disease influenced by genetic factors, particularly HLA-DRB1 alleles. The objective of this study was to characterize the distribution of HLA-DRB1 alleles in Chilean RA patients and healthy controls (
Diego Catalán, Lilian Soto, Lilian Soto, Óscar Neira, María C. Cuéllar-Gutiérrez, Roberto Díaz-Peña, Roberto Díaz-Peña, Octavio Aravena, Eduard Palou, Montserrat Carrascal, Juan C. Aguillón, Jaxaira Maggi   +11 more
doaj   +1 more source

Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation

Cell Death and Disease, 2018
Kidney transplantation is the optimal treatment for end-stage renal diseases. Although great improvement has been achieved, immune tolerance is still the Holy Grail that every organ transplant practitioner pursues.
Bo Peng, Y. Ming, Cheng Yang
semanticscholar   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Acquired Immune Tolerance in Mice to Crystalline Bovine Serum Albumin [PDF]

, 1959
Geronimo Terres, Walter L. Hughes
openalex   +1 more source

Immune tolerance in multiple sclerosis [PDF]

Immunological Reviews, 2011
Summary:  Multiple sclerosis is believed to be mediated by T cells specific for myelin antigens that circulate harmlessly in the periphery of healthy individuals until they are erroneously activated by an environmental stimulus. Upon activation, the T cells enter the central nervous system and orchestrate an immune response against myelin.
openaire   +2 more sources