Results 241 to 250 of about 367,328 (307)

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation. [PDF]

Adv Sci (Weinh)
Lu T, Song H, He L, Hu Z, Li Y, Xu C, Liu S, Jiang J, Zhou Y, Li Z, Li Z, Zhang K, Ma S, Qi R, Han S, Shi C, Wen W, Han D, Qin W.   +18 more
europepmc   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Innate immune recognition and microenvironmental reprogramming in HPV-induced cervical cancer: from pattern recognition receptor activation to immune tolerance disruption. [PDF]

Front Cell Infect Microbiol
Khan SU, Halawi MH, Almehmadi M, Taha R, Ahmed AE, Alfaifi MY, Shati AA, Elbehairi SEI, Ahmad S, Alanazi YF, Al-Rasheed M, Pandupuspitasari NS, Widiastuti E, Khan MU.   +13 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Emicizumab prophylaxis vs immune tolerance induction in children with severe hemophilia A and inhibitors: a retrospective comparison of bleeding control, quality of life, and cost. [PDF]

Res Pract Thromb Haemost
Li Z, Mao Q, Li G, Cheng X, Zhen Y, Liu G, Yao W, Li Z, Zhang J, Dong S, Ai D, Chen Z, Wu R.   +12 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Extracellular vesicles from <i>Akkermansia muciniphila</i> protect streptozotocin-induced diabetic mice by regulating glucose homeostasis, oxidative stress, and immune tolerance. [PDF]

Front Immunol
Chang Y, Zhang C, Li Z, Wang S, Wu J, Xie J, Cheng X.   +6 more
europepmc   +1 more source

Single coadministration of erythrocyte-uricase conjugate and immunosuppressant induces durable immune tolerance for gout therapy. [PDF]

Sci Adv
Nie X, Liu Y, Yao X, Wu C, Gao X.
europepmc   +1 more source

Editorial: Immune tolerance dual role: advancements in cancer and autoimmune diseases. [PDF]

Front Immunol
Bao S, Liu X, Wang CJ.
europepmc   +1 more source