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Tolerance and immune regulation
Immunology Today, 1991Understanding of both the phenomenon of immunological tolerance and the mechanisms by which it is achieved is rapidly advancing, as was evident from a recent meeting. This report summarizes key developments in both T- and B-cell biology.
Robey, Ellen, Urbain, Jacques
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Mucosal immunity and tolerance in the elderly
Mechanisms of Ageing and Development, 2004Age-associated dysregulation of the immune system of the gastrointestinal (GI) tract has been well documented for both secretory (S)-IgA immunity and oral tolerance. Thus, impaired antigen-specific Ab responses in aged animals and the elderly have been reported.
Jerry R. McGhee, Kohtaro Fujihashi
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Restoration of Immune Tolerance
2000The function of the immune response is to protect an organism from foreign material by first recognizing the material as foreign and then activating a cascade of events that leads to its removal. To perform this function without damaging the host, the immune system must distinguish between self and nonself, and target removal mechanisms only toward ...
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Immunity and tolerance: A unified concept
Cellular Immunology, 1971Immunity and Tolerance were first described and studied using living cells as antigen. This is not surprising since living cells constitute (as the basis for “self”) the main unit to be preserved as well as the main threat as potential parasitic invaders to complex living organisms.
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Production of Immune Tolerance in Humans
Nature, 1968IMMUNE tolerance has been established to a variety of antigens in many animal species1, but few data are available for humans2. The ease of inducing immune tolerance varies inversely with the maturity of the subject and the potency of the antigen. Humans are immunologically immature at birth.
Andres Acnayo +11 more
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The Liver and Immune Tolerance
2013As the largest solid organ in the body, the liver plays a critical role in metabolism and detoxification. Recently, emerging evidence suggests that the liver is an immunological organ with unique properties of predominant innate immunity and immune tolerance.
Zhe-Xiong Lian +3 more
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Science Signaling, 2014
Myeloid cells, innate lymphoid cells, and the cytokines they secrete cooperate to maintain immune tolerance in the gut.
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Myeloid cells, innate lymphoid cells, and the cytokines they secrete cooperate to maintain immune tolerance in the gut.
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NovoSeven® in immune tolerance therapy
Blood Coagulation & Fibrinolysis, 2000The development of inhibitors in haemophilia patients is one of the most serious challenges to effective treatment. The effect of factor (F) concentrate and treatment regimen on titre levels was studied in nine patients with haemophilia A or B and inhibitors.
L. Hess +4 more
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Transplantation Immunity and Tolerance
1961Publisher Summary This chapter discusses transplantation immunity and immunological tolerance, which are, under certain conditions, alternative reactions of the same organism to the same antigenic stimulus––namely, transplantation of tissues or cells from an antigenically different individual.
T. Hraba, A. Lengerová, Milan Hašek
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Immune Tolerance in Breast Cancer
Breast Disease, 2004In spite of the demonstrated coexistence of tumor-associated rejection antigens expressed by breast tumors along with T cells that are capable of recognize them, breast cancers arises in immunocompetent hosts, outmaneuver immune recognition and ultimately progress to widely disseminated disease.
Dmitry I. Gabrilovich +2 more
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