Results 41 to 50 of about 370,724 (274)

Decline of pertussis in hospitalised children following the introduction of immunisation in pregnancy – results from a nationwide, prospective surveillance study, 2013–2020

open access: yesSwiss Medical Weekly, 2021
Summary AIMS OF THE STUDY: Surveillance of pertussis at a national level is important to collect information on the epidemiology of the disease and to design optimal immunisation strategies.
Jana Zumstein, Ulrich Heininger
doaj   +1 more source

Administration of the Australian Childhood Immunisation Register [PDF]

open access: yes, 2015
This audit examined the effectiveness of the Department of Human Services’ administration of the Australian Childhood Immunisation Register. Audit objective, criteria and scope The audit objective was to examine the effectiveness of the Department of ...
Australian National Audit Office
core  

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

open access: yesAdvanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun   +18 more
wiley   +1 more source

Can a visual self-learning tool improve immunisation awareness? Evidence from a quasi-experimental pilot study in Madhya Pradesh, India

open access: yesBMC Public Health
Introduction Immunisation coverage in low- and middle-income countries continues to face challenges due to persistent gaps in vaccination schedule knowledge among caregivers and health workers.
Priyanka Das   +6 more
doaj   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu   +15 more
wiley   +1 more source

Effect of Health Education on Mothers’ Adherence to Childhood Immunisation Schedule at Dunkwa-On-Offin in the Upper Denkyira East Municipality of Ghana [PDF]

open access: yes, 2021
Immunisation is one of the most essential and cost-effective public health interventions for the prevention of childhood sicknesses and disabilities and a basic need for all children.
Adjedu, Sylvia Ahinee
core  

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

open access: yesAdvanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He   +6 more
wiley   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

open access: yesAdvanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi   +2 more
wiley   +1 more source

Systematic Literature Review of the Evidence for Effective National Immunisation Schedule Promotional Communications [PDF]

open access: yes, 2012
Introduction: A systematic literature review examined the published evidence on the effectiveness of European promotional communications for national immunisation schedule (NIS) vaccinations. The review was commissioned by the European Centre for Disease
Bowdler, Timothy   +5 more
core  

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng   +10 more
wiley   +1 more source

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