Results 61 to 70 of about 244,373 (296)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

The regulation of host defences to infection by the microbiota [PDF]

, 2016
The skin and mucosal epithelia of humans and other mammals are permanently colonised by large microbial communities (the microbiota). Due to this life-long association with the microbiota, these microbes have an extensive influence over the physiology of
Brown, RL, Clarke, TB
core   +1 more source

Mucocutaneous disease activity and damage accrual in systemic lupus erythematosus: analyses from the Asia‐Pacific Lupus Collaboration longitudinal cohort study

Arthritis Care &Research, Accepted Article.
Objective This research article aims to describe the prevalence, associations and health‐related quality‐of‐life (HRQoL) impact of mucocutaneous features of SLE. Methods Data from the Asia‐Pacific Lupus Collaboration cohort were analysed (2013‐2021). Mucocutaneous activity (MC‐A) items were rash, alopecia and mucosal ulcers; defined by the SLEDAI‐2K ...
Amanda M Saracino, Yanjie Hao, Dylan Hansen, Yi‐Hsing Chen, Alberta Hoi, Vera Golder, Jiacai Cho, Aisha Lateef, Worawit Louthrenoo, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Chak Sing Lau, Shirley Chan, Zhanguo Li, Hai‐hong Yao, Sargunan Sockalingam, BMDB Basnayake, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Jun Kikuchi, Yuko Kaneko, Tsutomu Takeuchi, Madelynn Chan, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Geraldine Hassett, Kristine(Pek Ling) Ng, Nicola Tugnet, Mark Sapsford, Yih Jia Poh, Michael Tee, Cherica Tee, Naoaki Ohkubo, Yoshiya Tanaka, Rangi Kandane‐Rathnayake, Eric Morand, Shereen Oon, Mandana Nikpour   +42 more
wiley   +1 more source

Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysis

Frontiers in Immunology, 2022
The role of the mucosal pulmonary antibody response in coronavirus disease 2019 (COVID-19) outcome remains unclear. Here, we found that in bronchoalveolar lavage (BAL) samples from 48 patients with severe COVID-19-infected with the ancestral Wuhan virus,
Maria Julia Ruiz, Maria Julia Ruiz, Maria Julia Ruiz, Gabriel Siracusano, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Daniela Tudor, Daniela Tudor, Daniela Tudor, Fernando Real, Fernando Real, Fernando Real, Aiwei Zhu, Aiwei Zhu, Aiwei Zhu, Claudia Pastori, Claude Capron, Arielle R. Rosenberg, Arielle R. Rosenberg, Arielle R. Rosenberg, Arielle R. Rosenberg, Nigel Temperton, Diego Cantoni, Hanqing Liao, Nicola Ternette, Pierre Moine, Mathieu Godement, Guillaume Geri, Guillaume Geri, Jean-Daniel Chiche, Djillali Annane, Elisabeth Cramer Bordé, Lucia Lopalco, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +36 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Protective Microbiota: From Localized to Long-Reaching Co-Immunity [PDF]

, 2017
Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance ...
Abt, Abt, Algburi, Altenhoefer, Altier, Anderson, Annuk, Asahara, Ashburner, Ayabe, Ayres, Barr, Barton, Bassis, Bassler, Becattini, Belkaid, Belkaid, Belkaid, Belkaid, Benson, Benveniste, Berg, Bevins, Birchenough, Birchenough, Blackburn, Bocci, Bohnhoff, Botes, Bouskra, Brandl, Braniste, Brenchley, Brestoff, Britton, Bron, Brugiroux, Budden, Buddington, Buffie, Buffie, Cani, Cani, Carey, Cash, Castagliuolo, Catford, Cebra, Cerf-Bensussan, Chatzidaki-Livanis, Chen, Chow, Chudnovskiy, Clarke, Clarke, Clarke, Cogen, Cogen, Cogen, Cotar, Cremer, Crost, Danielsson, Davidson, Davis, de Agüero, de Sablet, de Steenhuijsen Piters, Delhaes, Denny, Deriu, Dickson, Dickson, Dickson, Dickson, Donaldson, Donnet-Hughes, Eberl, El-Solh, Everett, Fagundes, Fardini, Fine, Fransen, Frantz, Franzenburg, Freter, Freter, Freter, Freter, Freter, Fubara, Fukuda, Gabryszewski, Gallichan, Gallo, Ganal, Gantois, Gauguet, Geva-Zatorsky, Gill, Gorjifard, Gutzeit, Henao-Mejia, Hersoug, Hibbing, Hooper, Hooper, Hooper, Hsiao, Ichinohe, Irie, Ivanov, Ivanov, Iwase, Kamada, Khosravi, Kinnunen, Knoop, Koch, Kolling, Kommineni, Laurent, Lawley, Levine, Little, Mack, Macpherson, Macpherson, Macpherson, Macpherson, Majlessi, Mallon, Maltby, Man, Mantis, Martins, Masson, Mazmanian, Mazmanian, McAleer, McKenney, Medzhitov, Melo, Mishra, Molloy, Murall, Mushin, Nagy, Nikkari, Oldroyd, Olier, Palm, Pamer, Pang, Perry, Pfeiffer, Pontier-Bres, Pradeu, Pradeu, Pradeu, Pérez-Santiago, Qin, Ramanan, Rasmussen, Rea, Rea, Ripert, Rizzetto, Robinson, Rolfe, Roossinck, Round, Ruhe, Råberg, Salzman, Sambanthamoorthy, Samuelson, Santagati, Santagati, Sassone-Corsi, Sassone-Corsi, Savage, Schamberger, Schieber, Schneider, Schuijt, Sharma, Shi, Shin, Shokouhfard, Shu, Siegrist, Soares, Sommer, Spees, Stapleton, Stappenbeck, Stecher, Stecher, Stinson, Strugnell, Sutyak Noll, Tanaka, Theriot, Tillmann, Tomkovich, Tomás, Tuomola, Ubeda, Underhill, Vaishnava, Valdés-Varela, Valdés-Varela, Valle, Van de Perre, van der Waaij, Vandecandelaere, Venkataraman, Villarino, Virgin, Virgin, Walker, Walsham, Weaver, Weingarden, Wexler, Whiteson, Wikoff, Willis, Wootton, Wright, Wu, Xiang, Yilmaz, Zagato, Zeng, Zipperer   +238 more
core   +4 more sources

Mucosal Immunity/Mucosal Vaccine

Nippon Shokuhin Kagaku Kogaku Kaishi, 2009
ヒトや動物には，外敵から身体を守るために免疫系が備わっている．多くのウイルスや病原菌の侵入口である粘膜面には効果的な「粘膜免疫」が存在し，抗原特異的分泌型IgA応答や細胞障害性T細胞（CTL）を誘導する．各粘膜は共通粘膜免疫機構（common mucosal immune system（CMIS））により関連をもち，ある粘膜組織で誘導されたIgA産生細胞やCTLは他の粘膜組織にも帰巣（ホーミング）する．とくに，分泌型IgA産生細胞は，腸管関連リンパ組織（GALT），鼻咽頭関連リンパ組織（NALT）および気管支関連リンパ組織（BALT）などの誘導組織（inductive site）で誘導され，実効組織（effector site）である腸管粘膜固有層，呼吸器粘膜固有層，乳腺，涙腺，唾液腺 ...
openaire   +2 more sources

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Interplay Between Oral Microbiota and Mouth Health in People Living With HIV Under Antiretroviral Therapy With or Without Periodontitis

International Journal of Dentistry
People living with HIV (PLWH) in combined antiretroviral therapy (cART) face microbiota shifts linked to immune status, ART regimen, and periodontal diseases, which are capable of inducing local and systemic inflammation.
Diana Estefania Ramos Peña, Oulfa Boussetta-Charfi, Angéline Antezack, Nacera Amroune, Philippe Colson, Virginie Monnet-Corti, Rafael Simone Saia, Johann Guillemot, Bruno Pozzetto, Sylvie Pillet, Bernard La Scola, Thomas Bourlet, Ana Carolina Fragoso Motta   +12 more
doaj   +1 more source

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques. [PDF]

, 2019
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood.
Dinasarapu, Ashok R, Durbin-Johnson, Blythe P, Elizaldi, Sonny R, Iyer, Smita S, Kozlowski, Pamela A, Raeman, Reben, Rolston, Matthew, Settles, Matthew, Verma, Anil, Walter, Korey A   +9 more
core   +1 more source