Results 61 to 70 of about 637,260 (296)

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization [PDF]

, 2021
While current COVID-19 vaccines provide certain protection, more effective vaccination strategies are still desirable. Here the authors show, using mouse vaccination models, that priming with a systemic mRNA and boosting with an intranasal adenoviral ...
Uhlig, Nadja, Fraedrich, Kirsten, Ana Vieira Antão, Anna Schmidt, Thomas Grunwald, Thirion, Christian, Markus Hoffmann, Christian Thirion, Willar, Jonas, Cordula Pertl, Nadja Uhlig, Torsten Willert, Hoffmann, Markus, Kirsten Fraedrich, Lapuente, Dennis, Irrgang, Pascal, Jonas Willar, Hoiffmann, Markus, Valentina Eberlein, Jana Fuchs, Pöhlmann, Stefan, Grunwald, Thomas, Ensser, Armin, Schmidt, Anna, Oltmanns, Friederike, Leila Issmail, Armin Ensser, Friederike Oltmanns, Fuchs, Jana, Klaus Überla, Antonia Sophia Peter, Überla, Klaus, Tenbusch, Matthias, Sandra Mueller-Schmucker, Andrea Cara, Mueller-Schmucker, Sandra, Dennis Lapuente, Antão, Ana Vieira, Eberlein, Valentina, Cara, Andrea, Issmail, Leila, Willert, Torsten, Stefan Pöhlmann, Cara, Andrrea, Pascal Irrgang, Peter, Antonia Sophia, Pertl, Cordula, Matthias Tenbusch, Mueller-Schmucker, Sandra; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Pöhlmann, Stefan; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany, Lapuente, Dennis; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Willar, Jonas; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Fuchs, Jana; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Ensser, Armin; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Tenbusch, Matthias; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Uhlig, Nadja; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany, Eberlein, Valentina; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany, Schmidt, Anna; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Vieira Antão, Ana; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Thirion, Christian; Sirion Biotech, Martinsried, Germany, Vieira Antão, Ana, Pertl, Cordula; Sirion Biotech, Martinsried, Germany, Oltmanns, Friederike; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Willert, Torsten; Sirion Biotech, Martinsried, Germany, Peter, Antonia Sophia; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Grunwald, Thomas; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany, Überla, Klaus; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Fraedrich, Kirsten; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Irrgang, Pascal; Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, Issmail, Leila; Fraunhofer Cluster of Excellence Immune-mediated Diseases CIMD, Frankfurt am Main, Germany, Hoffmann, Markus; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany, Cara, Andrea; National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy   +71 more
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Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Interplay Between Oral Microbiota and Mouth Health in People Living With HIV Under Antiretroviral Therapy With or Without Periodontitis

International Journal of Dentistry
People living with HIV (PLWH) in combined antiretroviral therapy (cART) face microbiota shifts linked to immune status, ART regimen, and periodontal diseases, which are capable of inducing local and systemic inflammation.
Diana Estefania Ramos Peña, Oulfa Boussetta-Charfi, Angéline Antezack, Nacera Amroune, Philippe Colson, Virginie Monnet-Corti, Rafael Simone Saia, Johann Guillemot, Bruno Pozzetto, Sylvie Pillet, Bernard La Scola, Thomas Bourlet, Ana Carolina Fragoso Motta   +12 more
doaj   +1 more source

Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysis

Frontiers in Immunology, 2022
The role of the mucosal pulmonary antibody response in coronavirus disease 2019 (COVID-19) outcome remains unclear. Here, we found that in bronchoalveolar lavage (BAL) samples from 48 patients with severe COVID-19-infected with the ancestral Wuhan virus,
Maria Julia Ruiz, Maria Julia Ruiz, Maria Julia Ruiz, Gabriel Siracusano, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Daniela Tudor, Daniela Tudor, Daniela Tudor, Fernando Real, Fernando Real, Fernando Real, Aiwei Zhu, Aiwei Zhu, Aiwei Zhu, Claudia Pastori, Claude Capron, Arielle R. Rosenberg, Arielle R. Rosenberg, Arielle R. Rosenberg, Arielle R. Rosenberg, Nigel Temperton, Diego Cantoni, Hanqing Liao, Nicola Ternette, Pierre Moine, Mathieu Godement, Guillaume Geri, Guillaume Geri, Jean-Daniel Chiche, Djillali Annane, Elisabeth Cramer Bordé, Lucia Lopalco, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +36 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity

, 2013
Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see ...
Chul Ho Lee, S H Cho, Jung Hwan Hwang, Sang-Moo Shim, H H Bae, E K Ryu, Young Woock Noh, H S Park, Y T Lim, Haryoung Poo, J H Hong, M H Sung   +11 more
core   +1 more source

Control of mucosal defense and innate immunity by neuroregulators

, 2018
Mucosal surfaces are constantly exposed to environmental insults, being susceptible to infection, inflammation and tissue damage. At these sites, an integrated network of non-hematopoietic and hematopoietic cells is critical to maintain epithelial ...
Cardoso, Vânia
core   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

Mucosal immunity to HSV infection [PDF]

, 1997
This study was designed to explore different mucosal immunization strategies for inducing immunity to HSV and, additionally, to understand the immunological mechanisms protecting against vaginal Herpes Simplex Virus (HSV) infection.
Kuklin, Nelly Alexandrova
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