Results 1 to 10 of about 244,081 (296)

Mucosal immunity in cancer metastasis: roles, mechanisms, and therapeutic implications [PDF]

Frontiers in Immunology
Previous studies have shown that the mucosal immune system plays a crucial role in regulating immune tolerance, maintaining the integrity of the mucosal barrier, and facilitating immune communication between organs.
Yaru Miao, Dongdong Cui, Yanghui Bi, Ruiping Zhang   +3 more
doaj   +2 more sources

The Protective HIV-1 Envelope gp41 Antigen P1 Acts as a Mucosal Adjuvant Stimulating the Innate Immunity

Frontiers in Immunology, 2021
Mucosal nasal vaccine development, although ideal to protect from pathogens invading mucosally, is limited by the lack of specific adjuvant. We recently used P1, a conserved region of HIV-1 gp41-envelope glycoprotein, as efficient antigen in a ...
Lin Xu, Lin Xu, Lin Xu, Daniela Tudor, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +8 more
doaj   +1 more source

Mucosal Application of gp140 Encoding DNA Polyplexes to Different Tissues Results in Altered Immunological Outcomes in Mice [PDF]

, 2013
Increasing evidence suggests that mucosally targeted vaccines will enhance local humoral and cellular responses whilst still eliciting systemic immunity.
A Azizi, A Kantele, A Minne, BA Koblin, C Lindholm, CJ Wei, CM Rush, DL Woodland, H Jiang, J De Calisto, J Holmgren, Jamie F. S. Mann, JF Mann, JF Richmond, JH Song, John S. Tregoning, John Stambas, JR Mora, L Buonaguro, L Torrieri-Dramard, L Wu, LS Klavinskis, M Bivas-Benita, MA Arias, MR Neutra, Paul F. McKay, R Geiben-Lynn, Reeyeshkumar K. Patel, Robin J. Shattock, S Lu, S Mazumder, S Wang, Samantha Arokiasamy, SW Barnett, XD Yao, Z Wang   +35 more
core   +18 more sources

S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

Nature Communications, 2022
HIV-1 eradication is hindered by viral persistence in different cell reservoirs, including circulatory CD4+ T-cells and tissue-resident macrophages. Here, by analyzing male genital mucosa from cART-suppressed HIV1-infected individuals, Real et al.
Fernando Real, Aiwei Zhu, Boxin Huang, Ania Belmellat, Alexis Sennepin, Thomas Vogl, Céline Ransy, Marc Revol, Riccardo Arrigucci, Anne Lombès, Johannes Roth, Maria Laura Gennaro, Frédéric Bouillaud, Sarra Cristofari, Morgane Bomsel   +14 more
doaj   +1 more source

Protocol to detect infectious SARS-CoV-2 at low levels using in situ hybridization techniques

STAR Protocols, 2023
Summary: Low and persistent levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA/protein/virus can be detected in clinical samples months after infection, possibly related to the emergence of SARS-CoV-2 variants or development of ...
Andréa Cottignies-Calamarte, Feifan He, Aiwei Zhu, Fernando Real, Morgane Bomsel   +4 more
doaj   +1 more source

Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41

Frontiers in Immunology, 2020
Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
Maxence Duchemin, Maxence Duchemin, Maxence Duchemin, Daniela Tudor, Daniela Tudor, Daniela Tudor, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +11 more
doaj   +1 more source

Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission

Frontiers in Immunology, 2021
BackgroundThe vasodilator neuropeptide calcitonin gene-related peptide (CGRP) plays both detrimental and protective roles in different pathologies. CGRP is also an essential component of the neuro-immune dialogue between nociceptors and mucosal immune ...
Jammy Mariotton, Anette Sams, Emmanuel Cohen, Alexis Sennepin, Gabriel Siracusano, Francesca Sanvito, Lars Edvinsson, Nicolas Barry Delongchamps, Marc Zerbib, Lucia Lopalco, Morgane Bomsel, Yonatan Ganor   +11 more
doaj   +1 more source

Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model [PDF]

, 2016
Cryptosporidium is a major cause of severe diarrhea, especially in malnourished children. Using a murine model of C. parvum oocyst challenge that recapitulates clinical features of severe cryptosporidiosis during malnutrition, we interrogated the effect ...
A Blikslager, A Sheoran, AC White, AF Allam, AG Buret, AJ Benitez, AM Marchiando, Ana M. Lara, B Pantenburg, BA Leav, BD Kirkpatrick, BP Coutinho, BS Sheridan, C Maillot, C Wang, Carrie A. Cowardin, Cirle A. Warren, CR Weber, D Mondal, David T. Bolick, DG Agnew, DI Campbell, DT Bolick, DT Bolick, EA Maier, Edna I. Zaenker, EM Brown, F Heller, Francisco Jose Noronha, G Gorfu, G Widmer, GA Preidis, Glynis L. Kolling, Gregory A. Buck, HC Wang, HN Ehigiator, IC Castro, J Liu, James K. Roche, JB Parr, JE Galen, Jerrold R. Turner, JK Roche, JK Tumwine, John H. Moore, Joseph M. Vinetz, JR Mead, JR Turner, JW Priest, JY Chai, K Mølbak, KL Kotloff, KM D'Auria, L Lantier, L Lantier, LA Bartelt, LA Bartelt, LB Costa, LB Costa, Luther A. Bartelt, M Abe, M Barrier, M Deng, M Eguchi, M Jalovecká, M Kváč, M Taniuchi, MA Laxer, MA McArthur, MG Netea, MH Van Regenmortel, MJH Rytter, NR Klatt, OG Azevedo, P Medeiros, PA Manque, PA Manque, PC Okhuysen, PS Korpe, PS Korpe, R Haque, R Wahid, RD Newman, RE Black, Richard L. Guerrant, RP Lazarus, S Bhuiyan, S Lacroix-Lamandé, S Lacroix-Lamandé, S Sagodira, SC Nalle, SM Guk, SM Planchon, SP O'Hara, SP Spencer, SS Ajjampur, T Gebhardt, T Hoang, T Kinugasa, VA Cama, W Checkley, W Checkley, W Checkley, W Chen, YG Zhang, YH Su   +105 more
core   +10 more sources

Tuberculosis Risk Stratification of Psoriatic Patients Before Anti-TNF-α Treatment

Frontiers in Immunology, 2021
Psoriasis is a skin inflammatory condition for which significant progress has been made in its management by the use of targeted biological drugs. Detection of latent M.
Farida Benhadou, Violette Dirix, Fanny Domont, Fabienne Willaert, Anne Van Praet, Camille Locht, Françoise Mascart, Véronique Corbière   +7 more
doaj   +1 more source

Eliciting Mucosal Immunity [PDF]

New England Journal of Medicine, 2011
Eliciting mucosal immunity through vaccination has been problematic. Two recent studies suggest a strategy to achieve this goal.
Wayne I, Lencer, Ulrich H, von Andrian
openaire   +2 more sources