Results 21 to 30 of about 145,633 (259)

Cytokines and mucosal immunity [PDF]

Current Opinion in Gastroenterology, 2014
Cytokines are integral mediators for maintaining intestinal mucosal homeostasis, as well as prominent effector molecules during chronic gut inflammatory diseases. This review focuses on recent studies of the role of specific cytokines in mucosal immunity.Dichotomous, or even opposing, functions have been described for several cytokines involved in ...
Bamias, G., Arseneau, K.O., Cominelli, F.   +2 more
openaire   +3 more sources

Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre

Frontiers in Microbiology, 2017
In spite of there being a number of vaccines, influenza remains a significant global cause of morbidity and mortality. Understanding more about natural and vaccine induced immune protection against influenza infection would help to develop better ...
Victoria M. W. Gould, James N. Francis, Katie J. Anderson, Bertrand Georges, Alethea V. Cope, John S. Tregoning   +5 more
doaj   +1 more source

Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation

Cells, 2021
At the early stages of life development, alveoli are colonized by embryonic macrophages, which become resident alveolar macrophages (ResAM) and self-sustain by local division.
Florian Pierre Martin, Cédric Jacqueline, Jeremie Poschmann, Antoine Roquilly   +3 more
doaj   +1 more source

Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function

Frontiers in Immunology, 2022
The studies described here provide an analysis of the pathogenesis of Blau syndrome and thereby the function of NOD2 as seen through the lens of its dysfunction resulting from Blau-associated NOD2 mutations in its nucleotide-binding domain (NBD). As such,
Liming Mao, Liming Mao, Atika Dhar, Guangxun Meng, Guangxun Meng, Guangxun Meng, Ivan Fuss, Kim Montgomery-Recht, Zhiqiong Yang, Qiuyun Xu, Atsushi Kitani, Warren Strober   +11 more
doaj   +1 more source

Endoscopic Management of Gastric Varices: Efficacy and Outcomes of Gluing with N-Butyl-2-Cyanoacrylate in a North American Patient Population

Canadian Journal of Gastroenterology, 2008
BACKGROUND: Gastric variceal bleeding is associated with significant morbidity and mortality in patients with portal hypertension. Outside of North America, gastric variceal injection of N-butyl-2-cyanoacrylate has been shown to be safe and effective ...
PJ Belletrutti, J Romagnuolo, RJ Hilsden, F Chen, B Kaplan, J Love, PL Beck   +6 more
doaj   +1 more source

Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis

Frontiers in Immunology, 2017
Tuberculosis (TB) in young children differs from adult TB in that the risk of rapid progression to active TB (aTB) is higher in children than in adults. The reasons for this increased risk are not fully understood. Early differentiation remains difficult
Alexandra Dreesman, Véronique Corbière, Violette Dirix, Kaat Smits, Sara Debulpaep, Sara Debulpaep, Iris De Schutter, Myriam Libin, Mahavir Singh, Anne Malfroot, Camille Locht, Camille Locht, Camille Locht, Camille Locht, Françoise Mascart, Françoise Mascart   +15 more
doaj   +1 more source

Mucosal Immunization and Adjuvants [PDF]

, 2014
The goal of the influenza vaccine is to prevent influenza virus infection and control the yearly seasonal epidemic and pandemic. However, the presently available parenteral influenza vaccine induces only systemic humoral immunity, which does not prevent influenza virus infection on the mucosal surface. Secretary IGA antibodies play an important role in
Hasegawa, Hideki, van Reit, Elly, Kida, Hiroshi   +2 more
openaire   +2 more sources

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

Journal of Virology
AMP-activated protein kinase (AMPK) plays a central role in regulating cell energy balance. When activated, AMPK suppresses energy-consuming pathways, such as lipid and protein synthesis, while increasing nutrient availability through the activation of ...
Andrea Cottignies-Calamarte, Flora Marteau, Feifan He, Sandrine Belouzard, Jean Dubuisson, Daniela Tudor, Benoit Viollet, Morgane Bomsel   +7 more
doaj   +1 more source

c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

eLife, 2020
RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22.
Caroline Tizian, Annette Lahmann, Oliver Hölsken, Catalina Cosovanu, Michael Kofoed-Branzk, Frederik Heinrich, Mir-Farzin Mashreghi, Andrey Kruglov, Andreas Diefenbach, Christian Neumann   +9 more
doaj   +1 more source

Immuno-Diagnosis of Active Tuberculosis by a Combination of Cytokines/Chemokines Induced by Two Stage-Specific Mycobacterial Antigens: A Pilot Study in a Low TB Incidence Country

Frontiers in Immunology, 2022
Active tuberculosis (aTB) remains a major killer from infectious disease, partially due to delayed diagnosis and hence treatment. Classical microbiological methods are slow and lack sensitivity, molecular techniques are costly and often unavailable ...
Violette Dirix, Philippe Collart, Anne Van Praet, Maya Hites, Nicolas Dauby, Nicolas Dauby, Sabine Allard, Judith Racapé, Mahavir Singh, Camille Locht, Françoise Mascart, Véronique Corbière   +11 more
doaj   +1 more source