Results 21 to 30 of about 598,079 (287)

Mucosal immunity and vaccines [PDF]

Nature Medicine, 2005
There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of the mucosal immune system and discuss advances in the development of mucosal
Jan, Holmgren, Cecil, Czerkinsky
openaire   +2 more sources

Optimisation of ex vivo memory B cell expansion/differentiation for interrogation of rare peripheral memory B cell subset responses [version 2; referees: 2 approved]

Wellcome Open Research, 2018
Background: Human memory B cells play a vital role in the long-term protection of the host from pathogenic re-challenge. In recent years the importance of a number of different memory B cell subsets that can be formed in response to vaccination or ...
Luke Muir, Paul F. McKay, Velislava N. Petrova, Oleksiy V. Klymenko, Sven Kratochvil, Christopher L. Pinder, Paul Kellam, Robin J. Shattock   +7 more
doaj   +1 more source

Streptococcal Serine-Rich Repeat Proteins in Colonization and Disease

Frontiers in Microbiology, 2020
Glycosylation of proteins, previously thought to be absent in prokaryotes, is increasingly recognized as important for both bacterial colonization and pathogenesis.
Jia Mun Chan, Andrea Gori, Angela H. Nobbs, Robert S. Heyderman   +3 more
doaj   +1 more source

Experimental Models of Inflammatory Bowel DiseasesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
The understanding of the intestinal inflammation occurring in the inflammatory bowel diseases (IBD) has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation.
Patricia Kiesler, Ivan J. Fuss, Warren Strober   +2 more
doaj   +1 more source

Early diagnosis of miliary tuberculosis in a hemodialysis patient by combining two interferon-γ-release assays: a case report

BMC Nephrology, 2020
Background Patients with end-stage renal disease undergoing chronic hemodialysis (HD) are at high risk to develop tuberculosis (TB) associated with a high mortality rate.
Florence Bonkain, Dieter De Clerck, Violette Dirix, Mahavir Singh, Camille Locht, Françoise Mascart, Véronique Corbière   +6 more
doaj   +1 more source

HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity [PDF]

, 2010
Includes bibliographical references (leaves 124-150).The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV).
Gumbi, Pamela
core   +1 more source

Monoclonal antibody against EV71 3Dpol inhibits the polymerase activity of RdRp and virus replication

BMC Immunology, 2019
Background Enterovirus A 71 (EV71) is a neurotropic virus that may lead to acute flaccid paralysis, encephalitis, cardiopulmonary failure or even death. No vaccine and defensive drug controlling EV71 is currently available, novel and efficient antiviral ...
Yaoming Li, Jie Yu, Xiuwen Qi, Huimin Yan   +3 more
doaj   +1 more source

Innate immunity against HIV: a priority target for HIV prevention research. [PDF]

, 2010
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W, ROMARIS M, LINDBLAD E, DONCEL G, BORROW P, Persephone Borrow, Borrow, P, LEHNER T, DE MAGISTRIS MT, Shattock, Robin J., MEDAGLINI, DONATA, Vyakarnam, Annapurna, PATTERSON S, Annapurna Vyakarnam, POLI G, EUROPRISE WORKING GROUP BOGERS W, KIRCHHOFF F, KELLY C, TOWERS G, SILVESTRI G, DEBRE P, Robin J Shattock, Shattock, RJ, SHATTOCK RJ, Vyakarnam Annapurna, Borrow, Persephone, Borrow Persephone, GOODIER M, null null, SPECK R, EUROPRISE Working Group, GEIJTENBEEK T, Vyakarnam, A, Shattock Robin J, WAGNER H., VYAKARNAM A   +35 more
core   +1 more source

Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre

Frontiers in Microbiology, 2017
In spite of there being a number of vaccines, influenza remains a significant global cause of morbidity and mortality. Understanding more about natural and vaccine induced immune protection against influenza infection would help to develop better ...
Victoria M. W. Gould, James N. Francis, Katie J. Anderson, Bertrand Georges, Alethea V. Cope, John S. Tregoning   +5 more
doaj   +1 more source

Mucosal Immunization and Adjuvants [PDF]

, 2014
The goal of the influenza vaccine is to prevent influenza virus infection and control the yearly seasonal epidemic and pandemic. However, the presently available parenteral influenza vaccine induces only systemic humoral immunity, which does not prevent influenza virus infection on the mucosal surface. Secretary IGA antibodies play an important role in
Hasegawa, Hideki, van Reit, Elly, Kida, Hiroshi   +2 more
openaire   +2 more sources