Results 41 to 50 of about 598,079 (287)

Mucosal immunity and vaccination [PDF]

FEMS Microbiology Letters, 1991
The gut mucosal immune system is a critical component of the body's defense against pathogenic organisms, especially those responsible for enteric infections associated with diarrhoeal disease. Attempts to vaccinate against infections of mucosal tissues have been less successful than vaccination against systemic infections, to a large extent reflecting
openaire   +2 more sources

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

Journal of Virology
AMP-activated protein kinase (AMPK) plays a central role in regulating cell energy balance. When activated, AMPK suppresses energy-consuming pathways, such as lipid and protein synthesis, while increasing nutrient availability through the activation of ...
Andrea Cottignies-Calamarte, Flora Marteau, Feifan He, Sandrine Belouzard, Jean Dubuisson, Daniela Tudor, Benoit Viollet, Morgane Bomsel   +7 more
doaj   +1 more source

Ontogeny of mucosal immunity and aging

, 2015
The mucosal immune system begins development in utero at as early as 40 days gestation, and by the time of birth all components of the system are in place and have the potential to effectively respond to antigenic challenge.
Gleeson, Maree, Cripps, Allan, Maree Gleeson, Gleeson, M, Allan W. Cripps, Cripps, AW   +5 more
core   +1 more source

Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract [PDF]

, 2010
Includes bibliographical references (leaves 85-103).T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly ...
Salkinder, Amy Leia
core   +1 more source

c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

eLife, 2020
RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22.
Caroline Tizian, Annette Lahmann, Oliver Hölsken, Catalina Cosovanu, Michael Kofoed-Branzk, Frederik Heinrich, Mir-Farzin Mashreghi, Andrey Kruglov, Andreas Diefenbach, Christian Neumann   +9 more
doaj   +1 more source

Immuno-Diagnosis of Active Tuberculosis by a Combination of Cytokines/Chemokines Induced by Two Stage-Specific Mycobacterial Antigens: A Pilot Study in a Low TB Incidence Country

Frontiers in Immunology, 2022
Active tuberculosis (aTB) remains a major killer from infectious disease, partially due to delayed diagnosis and hence treatment. Classical microbiological methods are slow and lack sensitivity, molecular techniques are costly and often unavailable ...
Violette Dirix, Philippe Collart, Anne Van Praet, Maya Hites, Nicolas Dauby, Nicolas Dauby, Sabine Allard, Judith Racapé, Mahavir Singh, Camille Locht, Françoise Mascart, Véronique Corbière   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Respiratory Viral Infection Alters the Gut Microbiota by Inducing Inappetence

mBio, 2020
Respiratory viral infections are extremely common, but their impacts on the composition and function of the gut microbiota are poorly understood. We previously observed a significant change in the gut microbiota after viral lung infection.
Helen T. Groves, Sophie L. Higham, Miriam F. Moffatt, Michael J. Cox, John S. Tregoning   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Safety and Immunogenicity of GTU®MultiHIV DNA Vaccine Delivered by Transcutaneous and Intramuscular Injection With or Without Electroporation in HIV-1 Positive Subjects on Suppressive ART

Frontiers in Immunology, 2019
Previous studies have shown targeting different tissues via the transcutaneous (TC) and intramuscular injection (IM) with or without electroporation (EP) has the potential to trigger immune responses to DNA vaccination.
G. Haidari, Suzanne Day, M. Wood, H. Ridgers, Alethea V. Cope, Sue Fleck, Celine Yan, Kalevi Reijonen, Drew Hannaman, Aggeliki Spentzou, Peter Hayes, A. Vogt, Behazine Combadiere, Adrian Cook, Sheena McCormack, Robin J. Shattock   +15 more
doaj   +1 more source