Results 11 to 20 of about 244,081 (296)

Antibody Fc-chimerism and effector functions: When IgG takes advantage of IgA

Frontiers in Immunology, 2023
Recent advances in the development of therapeutic antibodies (Abs) have greatly improved the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody activities are mediated by both their Fab and the Fc.
Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel   +5 more
doaj   +1 more source

Leptin and mucosal immunity [PDF]

Mucosal Immunology, 2012
Enhanced susceptibility to infection has long been recognized in children with congenital deficiency of leptin or its receptor. Studies in mice have demonstrated that leptin deficiency affects both the innate and acquired immune systems. Here, we review recent studies that demonstrate the impact on immunity of a common non-synonomous polymorphism of ...
Mackey-Lawrence, Nicole M., Petri, William A.   +1 more
openaire   +2 more sources

Mucosal dendritic cells shape mucosal immunity [PDF]

Experimental & Molecular Medicine, 2014
Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells.
Chang, Sun-Young, Ko, Hyun-Jeong, Kweon, Mi-Na   +2 more
openaire   +2 more sources

Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection

Frontiers in Immunology, 2022
The new pandemic virus SARS-CoV-2 is characterized by uncontrolled hyper-inflammation in severe cases. As the IL-22/IL-22R1 axis was reported to be involved in inflammation during viral infections, we characterized the expression of IL-22 receptor1, IL ...
Nurhan Albayrak, Carmen Orte Cano, Sina Karimi, David Dogahe, Anne Van Praet, Audrey Godefroid, Véronique Del Marmol, David Grimaldi, Benjamin Bondue, Jean-Paul Van Vooren, Jean-Paul Van Vooren, Françoise Mascart, Véronique Corbière   +12 more
doaj   +1 more source

The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis [PDF]

, 2017
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of prematurity. Although the precise cause is not well understood, the main risk factors thought to contribute to NEC include prematurity, formula feeding, and bacterial ...
Bolock, Alexa M, Good, Misty, Hodzic, Zerina   +2 more
core   +2 more sources

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis

Frontiers in Immunology, 2018
The protective efficacy of human immunodeficiency virus-1 (HIV-1) antibodies (Abs) remains mostly correlated with their in vitro neutralizing activity engaging their Fab region.
Maxence Duchemin, Maxence Duchemin, Maxence Duchemin, Marwa Khamassi, Marwa Khamassi, Marwa Khamassi, Lin Xu, Lin Xu, Lin Xu, Daniela Tudor, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +14 more
doaj   +1 more source

Specific Host Signatures for the Detection of Tuberculosis Infection in Children in a Low TB Incidence Country

Frontiers in Immunology, 2021
Diagnosis of tuberculosis (TB) in children remains challenging due to unspecific clinical presentation and low bacillary load. In low TB incidence countries, most cases are diagnosed by a contact screening strategy after exposure to an index TB case. Due
Alexandra Dreesman, Alexandra Dreesman, Véronique Corbière, Myriam Libin, Judith Racapé, Judith Racapé, Philippe Collart, Mahavir Singh, Camille Locht, Françoise Mascart, Violette Dirix   +10 more
doaj   +1 more source

Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame. [PDF]

, 2015
The polio eradication endgame aims to bring transmission of all polioviruses to a halt. To achieve this aim, it is essential to block viral replication in individuals via induction of a robust mucosal immune response. Although it has long been recognized
Anis E, Davis DC, Edward PK Parker, Ghendon YZ, Glezen WP, Glezen WP, Herremans MM, Herremans TM, Hovi T, Kathleen M O’Reilly, Margarita Pons-Salort, Marine WM, Natalie A Molodecky, Nicholas C Grassly, Ogra PL, Wehrle PF, WHO Collaborative Study Group on Oral and Inactivated Poliovirus Vaccines   +16 more
core   +3 more sources

Using the nonhuman primate model of HCMV to guide vaccine development. [PDF]

, 2014
The natural history of human cytomegalovirus (HCMV) is inextricably associated with mucosal surfaces. The vast preponderance of primary infections occur following mucosal exposure to infectious virions, and the high seroprevalence of HCMV throughout the ...
Barry, Peter A, Deere, Jesse D
core   +3 more sources

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. [PDF]

, 2013
ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with ...
Albanese, Anthony, Asmuth, David M, Devaraj, Sridevi, Douek, Daniel C, Flynn, Neil M, Garcia, Juan-Carlos, Knight, Thomas H, Ma, Zhong-Min, Miller, Christopher J, Sandler, Netanya G, Tsuchida, Emily, Wu, Tsung-Teh, Yotter, Tammy   +12 more
core   +1 more source