Results 121 to 130 of about 2,087,401 (308)

The Yonkers Case: Separation of Powers as a Yardstick for Determining Official Immunity [PDF]

, 1989
The author examines the application of the official immunity doctrine to a situation where a federal district court issued contempt citations to local legislators in Yonkers who refused to pass legislation as required by a consent decree.
Walsh, Amy
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Inborn Errors of Immunity Adolescents at School

Journal of Human Immunity
BackgroundAdolescents with inborn errors of immunity (IEI) experience disease-related absenteeism and psychosocial challenges that can compromise schooling.
Jacques G. Rivière, Laura Lopez-Seguer, Sonia Rodriguez-Tello, Miriam Gonzalez-Amores, Andrea Martin-Nalda, Saida Ridao-Manonellas, Sonia Galindo-Maicas, Carlota Villar-Amer, Pere Soler-Palacín   +8 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

Nature Communications
Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection ...
Samuel Speaks, Matthew I. McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E. Roettger, Adam D. Kenney, Hannah Bone, Lizhi Zhang, Parker J. Denz, Adrian C. Eddy, Amal O. Amer, Richard T. Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, Jacob S. Yount   +17 more
doaj   +1 more source

Biovail v. Hoechst Aktiengesellschaf, Inc: An Analysis Under the Sherman Act and the Noerr-Pennington Doctrine [PDF]

, 2017
The Hatch-Waxman Act of 1984 regulates approval by the Food and Drug Administration (“FDA”) of generic counterparts to patented drugs. In a series of recent cases, large pharmaceutical companies have been accused of exploiting Hatch-Waxman in violation ...
Resek, John F., Ph.D.
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Corrigendum to “Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients”

Journal of Immunology Research, 2022
Long-Shan Ji, Qiu-Tian Gao, Ruo-Wen Guo, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, XiaoJun Zhu, Ya-Ting Gao, Xue-Hua Sun, Yue-Qiu Gao, Man Li   +10 more
doaj   +1 more source

Batch Correction and Comparison of Intracellular Signaling Among Multiple Rheumatic and Inflammatory Diseases

Journal of Probability and Statistics
Assays that measure intracellular signaling can provide an especially mechanistic assessment of cellular states and are thereby useful for uncovering cellular physiology.
Tyson H. Holmes, Michael Couse, Yael Rosenberg-Hasson, Rosemary Fernandez, Ajay Fernandez, Kavita Mathi, Joel M. Guthridge, Judith A. James, Julie M. Yabu, Francois Haddad, P. J. Utz, Antonio Hardan, C. Garrison Fathman, Mark M. Davis, Holden T. Maecker   +14 more
doaj   +1 more source

Developing a Vaccine Against Human Cytomegalovirus: Identifying and Targeting HCMV’s Immunological Achilles’ Heel

Vaccines
Human cytomegalovirus (HCMV) is a critical pathogen in immunocompromised populations, such as organ transplant recipients as well as congenitally infected neonates with immature immune systems. Despite decades of research and the growing financial burden
Anastasia Lankina, Marta Raposo, Alexander Hargreaves, Claire Atkinson, Paul Griffiths, Matthew B. Reeves   +5 more
doaj   +1 more source