Results 131 to 140 of about 1,336,779 (318)

Inborn Errors of Immunity Adolescents at School

Journal of Human Immunity
BackgroundAdolescents with inborn errors of immunity (IEI) experience disease-related absenteeism and psychosocial challenges that can compromise schooling.
Jacques G. Rivière, Laura Lopez-Seguer, Sonia Rodriguez-Tello, Miriam Gonzalez-Amores, Andrea Martin-Nalda, Saida Ridao-Manonellas, Sonia Galindo-Maicas, Carlota Villar-Amer, Pere Soler-Palacín   +8 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Influence of tumours on protective anti-tumour immunity and the effects of irradiation

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan G. Pockley, Foulds, GA, Gemma A. Foulds, Alan Graham Pockley, Kreuzer, M, Gemma Ann Foulds, Radons, J., Gabriele eMulthoff, Radons, J, Pockley, AG, Kreuzer, M., Foulds, G.A., Jürgen eRadons, Jürgen Radons, Multhoff, G., Gabriele Multhoff, Mira eKreuzer, Pockley, A.G., Multhoff, G, Mira Kreuzer   +19 more
core   +1 more source

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

Nature Communications
Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection ...
Samuel Speaks, Matthew I. McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E. Roettger, Adam D. Kenney, Hannah Bone, Lizhi Zhang, Parker J. Denz, Adrian C. Eddy, Amal O. Amer, Richard T. Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, Jacob S. Yount   +17 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Corrigendum to “Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients”

Journal of Immunology Research, 2022
Long-Shan Ji, Qiu-Tian Gao, Ruo-Wen Guo, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, XiaoJun Zhu, Ya-Ting Gao, Xue-Hua Sun, Yue-Qiu Gao, Man Li   +10 more
doaj   +1 more source

Baseline data collections of lipopolysaccharide content in 414 herbal extracts and its role in innate immune activation

Scientific Reports
Some herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts.
Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma   +7 more
doaj   +1 more source

Developing a Vaccine Against Human Cytomegalovirus: Identifying and Targeting HCMV’s Immunological Achilles’ Heel

Vaccines
Human cytomegalovirus (HCMV) is a critical pathogen in immunocompromised populations, such as organ transplant recipients as well as congenitally infected neonates with immature immune systems. Despite decades of research and the growing financial burden
Anastasia Lankina, Marta Raposo, Alexander Hargreaves, Claire Atkinson, Paul Griffiths, Matthew B. Reeves   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

State Immunity in Jurisprudence of Czech Courts

, 2014
Th is paper discusses the understanding and application of the doctrine of State immunity in the courts of the Czech Republic. In 2008, the Czech Supreme Court reversed its previous conceptualization of State immunity as absolute and introduced a ...
Van der Ploeg, Klar Polackova
core