Results 171 to 180 of about 1,593,818 (299)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Temperature-Dependent Viral Pathogenicity: Implications for Attenuation of Viral Vaccines. [PDF]

Viruses
Shiraki K, Kawana T, Whitley RJ.
europepmc   +1 more source

Immune cells in the corpus luteum: friends or foes? [PDF]

, 2001
J. Pate
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Mucosal Adenovirus-Vectored Rv2299c Vaccine Protects Against Tuberculosis by Inducing Trained Immunity in Dendritic Cells and Polyfunctional T Cells. [PDF]

Vaccines (Basel)
Wang H, Xie S, Huang S, Huang X, Zhang Y, Wu J, Fan XY, Hu Z.   +7 more
europepmc   +1 more source

Innate immune molecular landscape following controlled human influenza virus infection

William Thistlethwaite, Sindhu Vangeti, Wan-Sze Cheng, Pankaj Agarwal, Antonio Cappuccio, Wenliang Wang, Bei Wei, Rachel A. Myers, Aliza B. Rubenstein, Daniel G. Chawla, Manoj Hariharan, Micah T. McClain, Thomas W. Burke, Steven H. Kleinstein, Joseph R. Ecker, Christopher W. Woods, William J. Greenleaf, Xi Chen, Irene Ramos, Elena Zaslavsky, Thomas G. Evans, Olga G. Troyanskaya, Stuart C. Sealfon   +22 more
openalex   +1 more source

Commentary: Immune cell infiltration and prognostic index in cervical cancer: insights from metabolism-related differential genes [PDF]

Fangshi Xu, Jiawei Lai
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Ecological determinants of altruism in prokaryote antivirus defense. [PDF]

Biol Direct
Biba DA, Makarova KS, Wolf YI, Waldron L, Koonin EV, Rochman ND.   +5 more
europepmc   +1 more source