Results 251 to 260 of about 2,570,818 (334)

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source

Editorial: Mucosal immunity after vaccination. [PDF]

Front Immunol
Arish M, López-Siles M, Naz F.
europepmc   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Promiscuity and specificity in ligand sensing by plant cell surface receptors. [PDF]

PLoS Pathog
Steidele CE, Gronnier J, Stegmann M, Hückelhoven R, Ried-Lasi MK.   +4 more
europepmc   +1 more source

STUDIES ON DENGUE FEVER I. STUDIES ON DENGUE VIRUS AND IMMUNITY. (2)

, 1948
N. Ishii
openalex   +2 more sources

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

The short chitooligosaccharide CO4 inhibits chitin-triggered immunity in grapevine and promotes the infection by Botrytis cinerea but not Plasmopara viticola. [PDF]

J Exp Bot
Marzari T, Villette J, Roudaire T, Palavioux K, Brulé D, Klinguer A, Héloir MC, Gayral M, Poinssot B.   +8 more
europepmc   +1 more source

ANTITUBERCULOUS IMMUNITY INDUCED IN MICE BY VACCINATION WITH LIVING CULTURES OF ATTENUATED TUBERCLE BACILLI

, 1953
René Dubos, Cynthia H. Pierce, Werner B. Schaefer   +2 more
openalex   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source

Detection of Immunity Gap before Measles Outbreak, Ho Chi Minh City, Vietnam, 2024. [PDF]

Emerg Infect Dis
Ong T, Thuy CT, Tam NH, Nga LH, Uyen NTV, Lan TTT, Tran A, Diem LTK, Khang HP, Dung DTX, Chuong LN, Tam NHT, Giang VC, Cam TTB, Anh HTN, Thu PTM, Man DNH, Dung NT, Tung NLN, Phat HH, Toan LM, Lam NT, Nguyen PNT, Nhung HN, Thanh TT, Chau NVV, Thuong TC, Thwaites G, Thwaites CL, Choisy M, Van Tan L.   +30 more
europepmc   +1 more source